University of Bristol

Academic Institute

No

CCU001

ACE inhibitors and angiotensin receptor blockers are drugs that are commonly used to lower high blood pressure. These drugs may affect the ability of the coronavirus to enter cells of the body and cause COVID-19. We plan to investigate whether use of these drugs affects people’s chance of becoming infected or unwell with COVID-19. We will conduct carefully planned analyses of data from millions of people’s healthcare records. These records provide information about people’s health and prescribed medications, as well as on which people became infected or unwell with COVID-19. People who take drugs to lower their blood pressure are more likely to have other risk factors for becoming infected or unwell with COVID-19. Our analysis methods will account for these risk factors, to work out whether any change in risk is due to the blood pressure lowering drugs themselves. Our results will help to inform the way that blood pressure lowering drugs are used in the future, particularly while the pandemic continues.

Our results will help to inform the way that blood pressure lowering drugs are used in the future, particularly while the pandemic continues. Visit the BHF Data Science Centre website for more detailed information about project outputs. https://bhfdatasciencecentre.org/projects/ccu001/

This project accessed the following datasets within the Trusted Research Environment(s) for CVD-COVID-UK / COVID-IMPACT: - ENGLAND: - Civil Registration - Deaths - COVID-19 SARI-Watch (formerly CHESS) - Covid-19 Second Generation Surveillance System - GPES Data for Pandemic Planning and Research (COVID-19) - Hospital Episode Statistics Accident and Emergency - Hospital Episode Statistics Admitted Patient Care - Hospital Episode Statistics Critical Care - Hospital Episode Statistics Outpatients - ICNARC: Intensive Care National Audit and Research Centre - Medicines dispensed in Primary Care (NHSBSA data) - NICOR – MINAP: Myocardial Ischaemia National Audit Project - NICOR – NACRM: National Audit of Cardiac Rhythm Management - NICOR – NACSA: National Adult Cardiac Surgery Audit - NICOR – NCHDA: National Congenital Heart Disease Audit - NICOR – NHFA: National Heart Failure Audit - NICOR – PCI: Percutaneous Coronary Interventions - NICOR – TAVI: Transcatheter Aortic Valve Implantation - Secondary Uses Services Payment By Results - Sentinel Stroke National Audit Programme Clinical Dataset - SCOTLAND: - COVID Tests - Diabetes covariates - General Acute Inpatient and Day Case - Scottish Morbidity Record (SMR01) - National Records of Scotland (NRS) - Deaths Data - NHS Scotland General Practice (GP) Contact Data - Subset - Outpatient Appointments and Attendances - Scottish Morbidity Record (SMR00) - Prescribing Information System (PIS) - Scotland Accident and Emergency - Scottish Stroke Care Audit - SICSAG Daily (Scottish Intensive Care Audit Group) - SICSAG Episodes (Scottish Intensive Care Audit Group) - WALES: - Annual District Death Daily (ADDD) - Annual District Death Extract (ADDE) - Care Home Dataset (CARE) - Covid Vaccination Dataset (CVVD) - COVID-19 Consolidated Deaths (CDDS) - COVID-19 Shielded People List (CVSP) - COVID-19 Test Results (PATD) - COVID-19 Test Trace and Protect (CTTP) - Legacy - Critical Care Dataset (CCDS) - Emergency Department Dataset (EDDS) - Emergency Department Dataset Daily (EDDD) - Intensive Care National Audit and Research Centre (ICCD) - Legacy - COVID only - Intensive Care National Audit and Research Centre (ICNC) - ONS 2011 Census Wales (CENW) - Outpatient Database for Wales (OPDW) - Outpatient Referral (OPRD) - Patient Episode Dataset for Wales (PEDW) - Welsh Demographic Service Dataset (WDSD) - Welsh Dispensing Dataset (WDDS) - Legacy - Welsh Longitudinal General Practice Dataset (WLGP) - Welsh Primary Care - Welsh Longitudinal GP Dataset - Welsh Primary Care (Daily COVID codes only) (GPCD) - Welsh Results Reports Service (WRRS)

30/10/2020

De-Personalised

TRE