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Large-Scale Analysis of Our Future Health Data to Facilitate Gene Discovery, Genome Sciences, and Genetic Medicines
Safe People
Organisation name
Regeneron
Organisation sector
2
Applicant name(s)
William Salerno
Funders/ Sponsors
Safe Projects
Project ID
OFHS240115
Lay summary
The primary scientific goal of this research is to accelerate our understanding of the role of genetics in human health and disease to motivate translation to genetic medicines. This goal will be accomplished by applying large-scale human genetics to OFH data. We will enable the identification of new drug targets, the validation of existing targets and therapeutics, and the discovery of biomarkers that may correlate with treatment responses. This research will also advance methods for discovery and validation of genetic variants that impact human health and disease. Discoveries in human genetics and genomics have paved the way for significant advances in science and medicine. Examples include identifying genetic causes of rare diseases and the improvement in their diagnosis and management. These efforts also support the discovery of cancer-associated mutations, the development of therapies and diagnostics, and observations of rare variants conferring protection from disease. Such findings have led to the development of important new medicines, routine genetic testing, and many other applications in research and clinical settings. Genetics research is greatly improved by large and diverse resources like OFH, allowing novel and rare variation to better inform the development of genetic medicines for the full human population.
Public benefit statement
The impact of this study will be profound, helping to advance our understanding of the genetic drivers of disease manifestation and progression in large and diverse populations. To this end, this findings of this study will help enhance early detection and prevention of chronic disease while also improving greatly the discovery and development of diagnostic and therapeutic innovations.
Request category type
Public Health Research
Other approval committees
Project start date
24/08/2024
Latest approval date
18/08/2024
Safe Data
Dataset(s) name