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Comparative effects of different antidiabetic treatments on COVID-19 mortality and vascular outcomes

Safe People

Organisation name

London School of Hygiene and Tropical Medicine

Organisation sector

Academic Institute

Applicant name(s)

Anna Schultze - Chief Investigator - London School of Hygiene & Tropical Medicine ( LSHTM )Anna Schultze - Corresponding Applicant - London School of Hygiene & Tropical Medicine ( LSHTM )Owen Taylor - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )Rohini Mathur - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )Selina Kim - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )

Safe Projects

Project ID

CPRD09

Lay summary

Type 2 Diabetes Mellitus (T2DM) is a common, chronic health condition in which a person’s glucose levels are too high. This can cause a range of complications, including damage to the eyes and kidneys, heart disease, stroke and heart attacks.

Technical summary

Type 2 Diabetes Mellitus (T2DM) affects approximately ~5% of individuals in the UK, and can cause both microvascular complications, such as retinopathy, kidney disease and neuropathy, as well as macrovascular complications, such as coronary heart disease, stroke, myocardial infarction and heart failure. More recently, individuals with T2DM have also been found to be at increased risk of COVID-19 mortality, a risk which is particularly marked for those with poorly controlled diabetes (HbA1c levels > 58 mmol/mol).

Latest approval date

26/05/2021

Safe Data

Dataset(s) name

ONS Death Registration Data

Patient Level Index of Multiple Deprivation

Practice Level Index of Multiple Deprivation

Safe Setting

Access type

Release