University of Cambridge

Academic Institute

No

CCU018

COVID-19 infection during pregnancy may increase the risk of cardiovascular health problems related to pregnancy and giving birth. Small hospital-based studies have suggested a relationship between COVID-19 infection during pregnancy and severe complications for mothers and their babies. However, since some complications are rare, detailed analyses from large population-based studies are required. Along with this, it is of great interest to understand the possible effect of vaccination against COVID-19 infection considering the increasing proportion of the population vaccinated against COVID-19 also among pregnant women. We will assess and quantify the role of COVID-19 infection and vaccination during pregnancy on COVID-19 related complications, cardiovascular-related maternal health outcomes (for example, pre-eclampsia, gestational hypertension, gestational diabetes, miscarriage, preterm birth, stillbirth, peripartum cardiomyopathy), and on longer-term cardiovascular related diseases for the mother and child. We will also compare the magnitude of the associations between pregnant women with and without pre-existing heart disease, we will explore the interaction between COVID-19 infection and climatic variables (for example air temperature and pollutions), and we will compare the magnitude of the associations of COVID-19 and influenza infections.

Results from our study will help to inform women on potential risks related to COVID-19 infection and vaccination during pregnancy, identify women with greatest risks, understand the possible protective effect of vaccination against COVID-19 infection, and help evaluate if any preventative interventions are needed. Visit the BHF Data Science Centre website for more detailed information about project outputs. https://bhfdatasciencecentre.org/projects/ccu016/

This project accessed the following datasets within the Trusted Research Environment(s) for CVD-COVID-UK / COVID-IMPACT: - ENGLAND: - Civil Registration - Deaths - COVID-19 SARI-Watch (formerly CHESS) - Covid-19 Second Generation Surveillance System - Covid-19 UK Non-hospital Antibody Testing Results - Covid-19 UK Non-hospital Antigen Testing Results - COVID-19 Vaccination Adverse Reaction - COVID-19 Vaccination Status - GPES Data for Pandemic Planning and Research (COVID-19) - Hospital Episode Statistics Accident and Emergency - Hospital Episode Statistics Admitted Patient Care - Hospital Episode Statistics Critical Care - Hospital Episode Statistics Outpatients - ICNARC: Intensive Care National Audit and Research Centre - Medicines dispensed in Primary Care (NHSBSA data) - NICOR – MINAP: Myocardial Ischaemia National Audit Project - NICOR – NHFA: National Heart Failure Audit - NICOR – PCI: Percutaneous Coronary Interventions - Secondary Care Prescribed Medicines (EPMA) - Secondary Uses Services Payment By Results - WALES: - Annual District Birth Extract (ADBE) - Annual District Death Daily (ADDD) - Annual District Death Extract (ADDE) - Care Home Dataset (CARE) - Covid Vaccination Dataset (CVVD) - COVID-19 Consolidated Deaths (CDDS) - COVID-19 Shielded People List (CVSP) - COVID-19 Test Results (PATD) - COVID-19 Test Trace and Protect (CTTP) - Legacy - Critical Care Dataset (CCDS) - Emergency Department Dataset (EDDS) - Emergency Department Dataset Daily (EDDD) - Intensive Care National Audit and Research Centre (ICCD) - Legacy - COVID only - Intensive Care National Audit and Research Centre (ICNC) - Maternity Indicators Dataset (MIDS) - Outpatient Database for Wales (OPDW) - Outpatient Referral (OPRD) - Patient Episode Dataset for Wales (PEDW) - Referral to Treatment Times (RTTD) - Welsh Ambulance Services NHS Trust (WASD) - Welsh Demographic Service Dataset (WDSD) - Welsh Dispensing Dataset (WDDS) - Legacy - Welsh Longitudinal General Practice Dataset (WLGP) - Welsh Primary Care - Welsh Longitudinal GP Dataset - Welsh Primary Care (Daily COVID codes only) (GPCD) - Welsh Results Reports Service (WRRS)

29/04/2021

De-Personalised

TRE