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Plasma elastase and severity of COVID19 disease
Safe People
Organisation name
NHS Lothian
Applicant name(s)
Dr Thomas Craven
Safe Projects
Project ID
DL-2020-026
Lay summary
White cells produce enzymes which help defeat invading disease-causing organisms. Some of these enzymes may also cause tissue damage and one in particular (elastase) may contribute to the invasion of coronavirus into lung tissue. No existing work has examined the relationship between circulating elastase and severity of coronavirus infection. Should a relationship be identified it opens up the possibility of using inhibitors of elastase as treatments for coronavirus infection. These inhibitors already exist as medical treatments, so they need only to repurposed not developed from scratch.
Request category type
Public Health Research
Latest approval date
19/04/2021
Safe Data
Dataset(s) name
Data sensitivity level
De-Personalised
Safe Setting
Access type
TRE