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EPINEF (Environmental Pollution-Induced Neurological Effects)
Population Size
0
People
Years
2014
Associated BioSamples
None/not available
Geographic coverage
Seoul
Korea
Lead time
Data only
Summary
The general population is exposed to numerous environmental pollutants, and it remains unclear which pollutants affect the brain, accelerating brain aging and increasing the risk of dementia. The Environmental-Pollution-Induced Neurological Effects study is a multi-city prospective cohort study aiming to comprehensively investigate the effect of different environmental pollutants on brain structures, neuropsychological function, and the development of dementia in adults.
DOI for dataset
Documentation
The EPINEF study was based on 6 prospective community-based cohorts (4 pre-existing and 2 newly established cohorts) involving areas with low, moderate, and high exposure risk (Figure 1). The 4 pre-existing cohorts included the Korean Genome and Epidemiology Study (KoGES) in Gangwha , the Korean Urban Rural Elderly cohort in Seoul , the Cardiovascular and Metabolic Diseases Etiology Research Center cohort in Seoul , and the Seoul incinerator cohort . The new cohorts were based in Namdong-gu, Incheon (where a large industrial complex is located) and Wonju/Pyeongchang (rural areas). The Seoul incinerator and Namdong cohorts, which include regions within a specific distance (300 m or 1 km) from the source of pollution (industrial complex region) were classified as having high exposure risk, whereas the KoGES and Wonju/Pyeongchang cohorts, which are considered as rural areas, were classified to have low exposure risk. The remaining cohorts were classified to have moderate exposure risk. By distinguishing between high exposure risk and moderate/low exposure risk based on the surrounding proximity of the industrial complex, we were able to obtain a basis for the classification of exposure and non-exposure to environmental pollutants and analyze differences between exposed and non-exposed regions. This multi-city design was chosen to obtain sufficient variation in the level of exposure to environmental pollutants. The survey centers were located at 3 university-based hospitals: Yonsei University Severance Hospital (Seoul and Gangwha), Gachon University Gil Medical Center (Incheon), and Wonju Severance Christian Hospital (Wonju and Pyeongchang).
Dataset type
Health and disease
Dataset sub-type
Not applicable, Neurological
Keywords
Provenance
Purpose of dataset collection
Study
Biological sample availability
None/not available
Details
Publishing frequency
Continuous
Version
1.0.0
Modified
17/02/2025
Coverage
Start date
01/05/2014
Time lag
Not applicable
Geographic coverage
Seoul, Korea
Minimum age range
60
Maximum age range
100
Follow-up
Continuous
Accessibility
Language
en
Alignment with standardised data models
OTHER
Controlled vocabulary
OTHER
Format
CSV
Data Access Request
Dataset pipeline status
Available
Access method category
TRE/SDE
Access service description
The Data Portal runs its analysis environment through a virtual desktop infrastructure accessible via VMWare software. By analysing the data in the virtual desktop environment you are working on DPUK's servers – meaning there is no physical transfer of data to researchers. The processing capacity enables you to work with large numbers of records and integrate these with the other data modalities that exist in the DPUK cohorts. This solution also offers researchers the freedom to conduct their analyses anywhere with an internet connection.
Data Processor
Dementias Platform UK