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Genetics of Asthma Severity & Phenotypes

Population Size

Not reported
Population Size statistic card

Years

2013 - 2020

Years statistic card

Associated BioSamples

None/not available

Associated BioSamples statistic card

Geographic coverage

United Kingdom

Geographic coverage statistic card

Lead time

Not applicable

Lead time statistic card

Summary

The Genetics of Asthma Severity & Phenotypes initiative was set up in 2013 as part of an Asthma UK funded programme of work to directly address the need for a large cohort of moderate-severe asthma patients for genetic studies.

Documentation

The Genetics of Asthma Severity & Phenotypes initiative was set up in 2013 as part of an Asthma UK funded programme of work to directly address the need for a large cohort of moderate-severe asthma patients for genetic studies.

The cohort was established by bringing together all of the major respiratory centres across the UK to provide access to existing samples/clinical data but also to prospectively recruit patients (still ongoing). This cohort has been utilised in our recent GWAS of Moderate-Severe asthma (PMID: 30552067).

The cohort is currently ~4,000 individuals and to date 2,536 individuals have Affymetrix Axion array data that has completed QC imputed to provide 33M variants. The cohort has extensive clinical and immunological data although absolute numbers of these measures are variable due to the nature of the formation of the cohort.

Dataset type

Health and disease

Dataset sub-type

Not applicable

Keywords

Provenance

Image contrast

Not stated

Biological sample availability

None/not available

Details

Publishing frequency

Annual

Version

1.0.0

Modified

08/10/2024

Distribution release date

12/01/2019

Citation Requirements

University of Nottingham

Coverage

Start date

01/01/2013

End date

01/01/2020

Time lag

Not applicable

Geographic coverage

United Kingdom

Maximum age range

150

Follow-up

1 - 10 Years

Accessibility

Language

en

Controlled vocabulary

LOCAL, NHS NATIONAL CODES

Format

CSV

Data Access Request

Dataset pipeline status

Not available

Time to dataset access

Not applicable

Access request cost

Data provision is free from SAIL. Overall project costing depends on the number of people that require access to the SAIL Gateway, the activities that SAIL needs to complete (e.g. loading non-standard datasets), data refreshes, analytical work required, disclosure control process, and special case technological requirements

Data use limitation

General research use

Data Controller

BREATHE

Data Processor

BREATHE

Dataset Types: Health and disease


Collection Sources:

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