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HCV Research UK

Population Size

Not reported
Population Size statistic card

Years

2012

Years statistic card

Associated BioSamples

DNA

Plasma

...see more

Associated BioSamples statistic card

Geographic coverage

United Kingdom

Scotland

Geographic coverage statistic card

Lead time

Other

Lead time statistic card

Summary

Collection of samples and data across the following diseases: Viral hepatitis type C

Documentation

HCV Research UK is a UK-wide consortium established in 2011 to underpin research into hepatitis C (HCV). This was achieved by establishing a biorepository and clinical research database. The biorepository is housed in the MRC-University of Glasgow Centre for Virus Research, directed by Dr John McLauchlan and managed by Dr Sarah McDonald. Samples have been obtained from around 10,000 patients. Access to samples and data is governed by a Tissue and Data Access Committee (TDAC). These are reviewed for ethical and scientific merit by TDAC and a decision reached. Serum and plasma are obtained from all patients in the cohort. Buffy coats are also collected, and DNA can be extracted when required. Additionally, peripheral blood mononuclear cells (PBMCs) and PAX gene tubes are held for smaller cohorts of patients. The extensive clinical data collected complements the biorepository and allows selection of samples from patients with characteristics of interest. Sub-cohorts:

  • Serial samples from patients who were treated as part of the NHS England Early Access Program.
  • Yearly samples from cirrhotic patients (beginning 2015)
  • Spontaneous resolvers
  • Small paediatric cohort Clinical Data
  • Basic demographics including place of birth and ethnicity
  • History of HCV infection including exposure to risk factors and dates
  • Date of diagnosis, date of first attendance at clinic
  • Co-morbidities and co-medications at time of enrolment
  • Liver disease status and how diagnosed
  • Treatment status at enrolment;
  • Social history including alcohol, cigarettes, cannabis; BMI
  • HCV RNA status, viral load and genotype/subtype
  • Historical data from the patients' notes regarding previous treatment episodes (dates, regimen, viral loads, outcome) and liver biopsies
  • Laboratory data including imaging and fibroscan;
  • New treatment episodes and changes in liver disease status are recorded over time, as are any newly developed co-morbidities. All data generated by researchers who access our biorepository must be returned into the database. Over time this will include host genetics, full length viral sequences, immunophenotyping and biomarker studies.

Dataset type

Health and disease

Dataset sub-type

Not applicable

Keywords

Provenance

Image contrast

Not stated

Biological sample availability

DNA,Plasma,Serum,Whole blood

Details

Publishing frequency

Other

Version

1.0.0

Modified

08/10/2024

Citation Requirements

In Progress

Coverage

Start date

01/01/2012

Time lag

Variable

Geographic coverage

United Kingdom, Scotland

Maximum age range

150

Accessibility

Language

en

Controlled vocabulary

LOCAL

Format

In Progress

Data Access Request

Dataset pipeline status

Not available

Access rights

Please contact the publisher using Contact Point details provided

Time to dataset access

Other

Access request cost

Not specified

Access method category

Varies based on project

Data Controller

University of Glasgow

Dataset Types: Health and disease


Collection Sources:

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