The Scottish HPV Archive is a biorepository of samples that provides a vital resource for researchers to improve the way we detect and manage HPV associated disease. The archive is housed within the Queen's Medical Research Institute, University of Edinburgh, and follows the governance policies of NHS Lothian for tissue collections and the bio-repository principles of the Lothian NRS Bioresource (SAHSC). It currently holds over 40,000 samples, the majority of which are cervical liquid-based cytology (LBC) samples although derivatives thereof (including nucleic acid) and other anogenital sample types are also available. For most of the samples, aliquots are kept at different temperatures (-80ËšC or -25ËšC) and different volumes (original sample and concentrated aliquot). The key attribute of the Scottish HPV archive is the annotation of samples with HPV and vaccination status as well as pathology information. Such linkage is possible in Scotland with the help of the Community Health Index (CHI), Scottish Cervical Call and Recall System (SCCRS) and Cancer Registry.