Bookmarks

CASPS: A Phase II trial of Cediranib in ASPS patients

Population Size

Not reported
Population Size statistic card

Years

2010

Years statistic card

Associated BioSamples

Availability to be confirmed

Associated BioSamples statistic card

Geographic coverage

United Kingdom

England

Geographic coverage statistic card

Lead time

Other

Lead time statistic card

Summary

Collection of samples and data across the following diseases: Malignant neoplasm of connective tissue (disorder)

Documentation

CASPS is a two-arm, randomised, double-blind, placebo-controlled, Phase II trial of cediranib in ASPS patients. The primary objective is to evaluate the efficacy of cediranib by measuring the percentage change in the sum of target marker lesion diameters from randomisation to week 24 compared to placebo. Secondary objectives include: progression-free survival, overall survival and safety and tolerability of cediranib in ASPS patients. Tissue markers of tumour response, circulating markers of angiogenesis, and changes in circulating endothelial cells/precursor cells in response to cediranib will be explored. Thirty six patients with progressive, metastatic, histologically confirmed ASPS will be recruited. Patients will be randomised to 24 weeks of blinded cediranib or placebo, after which treatment will be unblinded and all patients offered open-label cediranib until objective disease progression, or death if sooner.

Dataset type

Health and disease

Dataset sub-type

Not applicable

Keywords

Provenance

Image contrast

Not stated

Biological sample availability

Availability to be confirmed

Details

Publishing frequency

Other

Version

1.0.0

Modified

08/10/2024

Citation Requirements

In Progress

Coverage

Start date

01/01/2010

Time lag

Variable

Geographic coverage

United Kingdom, England

Accessibility

Language

en

Controlled vocabulary

LOCAL

Format

In Progress

Data Access Request

Dataset pipeline status

Not available

Access rights

Please contact the publisher using Contact Point details provided

Time to dataset access

Other

Access request cost

Not specified

Access method category

Varies based on project

Data Controller

The Institute of Cancer Research

Dataset Types: Health and disease


Collection Sources:

end of page