The Knee Pain and related health In the Community (KPIC) was initiated in 2014 as a prospective community-based cohort of 9500 people aged 40 years or over within the East Midlands region (UK). KPIC has, to date, completed 4 waves (0, 1, 3, 6 years) of questionnaire surveys, wave 6 administered within the context of the COVID-19 pandemic. Available data describe:

• demographic characteristics
• knee pain; pain severity, quality and distribution
• risk factors for knee pain and osteoarthritis (OA) (age, body mass index, knee alignment, nodal OA, index: ring finger length (2D4D ratio)
• quality of life (SF12)
• mental health (Hospital Anxiety and Depression Scale).

Clinical assessment/phenotyping of a subsample of 400 wave-0 participants plus 115 incidence knee pain cases was undertaken the first 3 waves. These baseline cases were purposively sampled from the KPIC population to comprise 3 groups: early knee pain (≤3 years), established knee pain or no knee pain. Available data include:

• knee radiographs (standing semi-flexed and 300 skyline views)
• knee ultrasound (synovial effusion, hypertrophy, and power Doppler)
• quantitative sensory testing (pressure pain detection thresholds and temporal summation)
• muscle strength (quadriceps, hip abductor, and hand-grip)
• measured balance
• gait analysis (GAITrite)
• blood and urine samples for biomarkers.