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Omega 3 Cohort
Population Size
75
People
Years
2021
Associated BioSamples
None/not available
Geographic coverage
United Kingdom
England
Lead time
Not applicable
Summary
A nutritional interventional study of middle-aged women with body pain, anxiety, depression, fatigue QoL serum and faecal biomarkers and baseline and follow-up.
Documentation
Prebiotics are compounds in food that benefit health via affecting the gut microbiome. Omega-3 fatty acids have been associated with differences in gut microbiome composition and are widely accepted to have health benefits, although recent large trials have been inconclusive. We carried out a 6-week dietary intervention comparing the effects of daily supplementation with 500 mg of omega-3 versus 20 g of a well-characterized prebiotic, inulin. Inulin supplementation resulted in large increases in Bifidobacterium and Lachnospiraceae. In contrast, omega-3 supplementation resulted in significant increases in Coprococcus spp. and Bacteroides spp, and significant decreases in the fatty-liver associated Collinsella spp. On the other hand, similar to the results with inulin supplementation which resulted in significant increases in butyrate, iso-valerate, and iso-butyrate (p < .004), omega-3 supplementation resulted in significant increases in iso-butyrate and isovalerate (p < .002) and nearly significant increases in butyrate (p < .053). Coprococcus, which was significantly increased post-supplementation with omega-3, was found to be positively associated with iso-butyric acid (Beta (SE) = 0.69 (0.02), P = 1.4 x 10-3) and negatively associated with triglyceride-rich lipoproteins such as VLDL (Beta (SE) = -0.381 (0.01), P = .001) and VLDL-TG (Beta (SE) = -0.372 (0.04), P = .001) after adjusting for confounders. Dietary omega-3 alters gut microbiome composition and some of its cardiovascular effects appear to be potentially mediated by its effect on gut microbial fermentation products indicating that it may be a prebiotic nutrient.
Dataset type
Health and disease
Dataset sub-type
Not applicable
Dataset population size
75
Associated media
Keywords
Observations
Observed Node | Disambiguating Description | Measured Value | Measured Property | Observation Date |
|---|---|---|---|---|
Persons | 75 | Count | 26 Sep 2021 |
Provenance
Purpose of dataset collection
Trial
Image contrast
Not stated
Biological sample availability
None/not available
Details
Publishing frequency
Static
Version
2.0.0
Modified
08/10/2024
Coverage
Start date
01/01/2021
Time lag
Not applicable
Geographic coverage
United Kingdom, England
Accessibility
Language
en
Alignment with standardised data models
OMOP
Controlled vocabulary
LOCAL
Format
csv
Data Access Request
Dataset pipeline status
Not available
Access rights
Time to dataset access
Not applicable
Jurisdiction
GB-ENG
Data Controller
University of Nottingham