Cardiac arrest (CA) is a leading cause of death in many countries – despite years of research, survival rates remain consistently low. Cardiopulmonary resuscitation (CPR) is an emergency procedure consisting of chest compressions combined with positive pressure ventilation, intended to restore flow of oxygenated blood to the brain and heart.

Dataset 1: 10 virtual subjects under cardiac arrest receiving cardiopulmonary resuscitation

• We aimed to use a high-fidelity computational model that captures key interactions between the cardiovascular and pulmonary systems to investigate whether current CPR protocols could potentially be improved.

Dataset 2: 10 virtual pregnant women (with normal and high body mass index)

• Hypoxaemia during general anaesthesia can cause harm. Apnoeic oxygenation extends safe apnoea time, reducing risk during airway management. We hypothesised that low-flow nasal oxygenation (LFNO) would extend safe apnoea time similarly to high-flow nasal oxygenation (HFNO), whilst allowing face-mask preoxygenation and rescue.

Dataset 3: 100 virtual healthy subjects

• During induction of general anaesthesia a ‘cannot intubate, cannot oxygenate’ (CICO) situation can arise, leading to severe hypoxaemia. Evidence is scarce to guide ventilation strategies for small-bore emergency front of neck airways that ensure effective oxygenation without risking lung damage and cardiovascular depression.