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University College London - Edinburgh-Bristol (UCLEB) multi-omics consortium

Population Size

30,000

People

Population Size statistic card

Years

1946

Years statistic card

Associated BioSamples

Availability to be confirmed

Associated BioSamples statistic card

Geographic coverage

United Kingdom

Geographic coverage statistic card

Lead time

Not applicable

Lead time statistic card

Summary

The UCLEB consortium of highly-phenotyped population-based prospective cohort studies provides a multi-omics data source consisting of genomics, metabolomics and proteomics for researching the molecular basis of disease and to inform drug development.

Documentation

The UCLEB consortium brings together well established prospective observational studies comprising over 30000 individuals from across the UK to interrogate genetic and biomarker associations underlying cardiovascular and other diseases. Participating studies include: Whitehall-II (WHII), British Regional Heart Study (BRHS), English Longitudinal Study of Ageing (ELSA), MRC National Survey of Health and Development (MRC NSHD), 1958 Birth Cohort (1958BC), Edinburgh Artery Study (EAS), Edinburgh Type 2 Diabetes Study (ET2DS), Edinburgh Heart Disease Prevention Study (EHDPS), the Aspirin for Asymptomatic Atherosclerosis Trial (AAAT), Caerphilly Prospective Study (CaPS), the British Women's Heart and Health Study (BWHHS), Southall and Brent Revisited (SABRE) and a subset of the UK Longitudinal Women's Cohort. The consortium enables research into the genomic and other determinants of disease using a range of genotyping panels (Cardiochip, n=8000; Metabochip, n=20,000; and the Infinium Human Core DrugDev array, n=20,000), as well as the Nightingale NMR metabolomics platform (>200 lipidomic and metabolomic measures) and the Somalogic Proteomics platform (>5000 circulating proteins)

Genotypes are currently imputed to the Haplotype Reference Consortium panel (HRC) providing a rich source of genetic variants used in Mendelian Randomisation and Drug Target Validation pipelines. The genotyping arrays have overlapping SNP content providing extensive and dense coverage of key areas of the human genome.

These data are complemented by a wide range of survey data collected by each study over several years including clinical surveys with a range of individually assayed biomarkers, as well as measures of cognitive, respiratory, cardiac, and renal function. There is also linkage to NHS health outcomes.

Data is hosted at UCL on the secure, access restricted servers with sensitive identifiable data on the UCL ISO27001 Data Safe Haven.

Individual cohort studies maintain independent data governance and ethics for core data. Data Access for UCLEB consortium data is granted via application to the UCLEB Steering group indicating which studies and datasets are required for proposed research. In some instances a further application to the individual study is required for bespoke datasets.

Dataset type

Health and disease

Dataset sub-type

Not applicable

Dataset population size

30000

Keywords

Observations

Observed Node

Disambiguating Description

Measured Value

Measured Property

Observation Date

Persons

Cardiochip, n=8000; Metabochip, n=20,000; and the Infinium Human Core DrugDev array, n=20,000, as well as the Nightingale NMR metabolomics platform >200 lipidomic and metabolomic measures) and the Somalogic Proteomics platform >5000 circulating proteins

30000

Count

01 Jun 2016

Provenance

Purpose of dataset collection

Study

Source of data extraction

Other

Collection source setting

Other

Image contrast

Not stated

Biological sample availability

Availability to be confirmed

Details

Publishing frequency

Irregular

Version

1.0.0

Modified

08/10/2024

Citation Requirements

UCLEB Consortium

Coverage

Start date

10/03/1946

Time lag

Variable

Geographic coverage

United Kingdom

Maximum age range

150

Follow-up

10 Years

Accessibility

Language

en

Controlled vocabulary

LOCAL

Format

text

Data Access Request

Dataset pipeline status

Not available

Access rights

In progress

Time to dataset access

Not applicable

Access request cost

Cost recovery

Jurisdiction

GB

Data use limitation

Research-specific restrictions,Research use only,No linkage

Data use requirements

Collaboration required,Ethics approval required,Geographical restrictions,Institution-specific restrictions,Not for profit use,Project-specific restrictions,Publication moratorium,Publication required,Return to database or resource,Time limit on use,User-specific restriction,Disclosure control

Data Controller

University College London University of Bristol University of Edinburgh

Data Processor

University College London University of Bristol University of Edinburgh

Dataset Types: Health and disease


Collection Sources: Other

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