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Our Future Health Genotype Array Data

Population Size

330,058

People

Years

2021 - 2024

Associated BioSamples

None/not available

Geographic coverage

United Kingdom

Lead time

Not applicable

Summary

Our Future Health is a prospective, observational cohort study of the general adult population of the United Kingdom. The dataset includes genotype array data on approximately 707, 522 variants and 651, 050 participants.

Documentation

Our Future Health is a prospective, observational cohort study of the general adult population of the United Kingdom (UK). The programme aims to support a wide range of observational health research. We gather personal, health and lifestyle information from each participant through a self-completed baseline health questionnaire and at an in-person clinic visit. We will further link this data to other health-related data sets. Participants have also given consent for us to recontact them, for example to invite them to take part in further or repeat data collections, or other embedded studies such as clinical trials.

The Our Future Health programme is currently open to all adults (18 years and older) living in the UK. In July 2022, we started recruiting participants in England and will continue to expand across the rest of the UK. The data we’ve gathered so far (September 2024) includes genotype array data on 707, 522 variants and 651, 050 participants.

These data were obtained using a custom Illumina Infinium Excalibur beadchip array, designed by Our Future Health in collaboration with Illumina. The array includes variants related to a wide range of health phenotypes, blood typing, pharmacogenetics, selected copy number variants, clinically relevant variants, and a “backbone” of variants to support imputation.

A separate, linked dataset is available that provides participant baseline demographic information and responses to our baseline health questionnaire. Clinical measurements data is also available from participants. Additionally linked NHS England data that provides clinical information on participants is also available.

The data is stored in the Our Future Health Trusted Research Environment. We de-identify all participant data we gather before it’s available for use. All researchers will need to become registered researchers at Our Future Health and have an approved research study before they're given access to the data.

We aim to collect a variety of data types from up to 5 million adult participants from across the UK. We hope to make more data types available on a quarterly basis.

Dataset type
Health and disease, Omics
Dataset sub-type
Genomics
Dataset population size
330,058

Keywords

Research, United Kingdom, Cohort study, Self-reported health, Mental health, Lifestyle, Sociodemographics, Genetic, genotype

Observations

Observed Node
Disambiguating Description
Measured Value
Measured Property
Observation Date

Persons

Persons who consented to joining Our Future Health, completed a questionnaire, have a good blood sample and genotype array data

651050

Count

17 Jan 2024

Provenance

Purpose of dataset collection
Study
Source of data extraction
Machine generated
Collection source setting
Clinic
Image contrast
Not stated
Biological sample availability
None/not available

Structural Metadata

Details

Publishing frequency
Quarterly
Version
1.0.0
Modified

08/10/2024

Distribution release date

12/12/2024

Citation Requirements
Our Future Health

Coverage

Start date

01/05/2021

End date

15/10/2024

Time lag
Other
Geographic coverage
United Kingdom
Minimum age range
18
Maximum age range
150
Follow-up
0 - 6 Months

Omics

Assay
Genotyping by array
Platform
Illumina

Accessibility

Language
en
Controlled vocabulary
LOCAL
Format
pVCF, BGEN, tsv, multiple formats available

Data Access Request

Dataset pipeline status
Not available
Time to dataset access
Not applicable
Access method category
TRE/SDE
Access service description

The Our Future Health Trusted Research Environment (TRE) is a highly secure computing environment, where researchers can access the Our Future Health data they have applied for. The TRE is subject to rules, monitoring, and strict controls to protect the data and participants' privacy.

The Our Future Health TRE has a range of tools available for analysing the data. More information is available here:

https://research.ourfuturehealth.org.uk/analysing-the-data/

If you think our TRE will not be able to meet your research needs, for example, if you’ve developed complex software or analytical tools that would be hard to recreate, you can apply to access the data using a different TRE.

Jurisdiction
GB-ENG
Data use limitation
Research use only
Data use requirements
Project-specific restrictions, Geographical restrictions, Return to database or resource, Time limit on use, User-specific restriction
Data Controller
Our Future Health

Dataset Types: Health and disease, Omics

Dataset Sub-types: Genomics


Collection Sources: No collection sources listed