Background: Age-related macular degeneration (AMD) is a degenerative disease of the human retina affecting individuals over the age of 55 years. AMD is the leading cause of blindness in industrialized countries. Worldwide, the number of people with AMD is predicted to increase from 196 million in 2020 to 288 million by 2040.

The UHB AMD Dataset is a longitudinal dataset consisting of routinely collected imaging and clinical metadata from patients receiving treatment for age-related macular degeneration (AMD) at UHB, from 2007 to the present.

This dataset encompasses all patients at UHB who have received at least one injection of either Lucentis (ranibizumab) or Eylea (aflibercept) or avastin. This dataset will include data from both eyes in each case - for example, it will include data from fellow eyes that are not receiving injections. For these reasons, the dataset will include longitudinal data from a mixture of eyes with both “dry” and “wet” AMD. Clinical metadata includes demographic information, visual acuities (predominantly measured with Early Treatment Diabetic Retinopathy Study (ETDRS) charts), treatment, and outcomes.

This dataset is continuously updating, however, as of October 2021, it consisted of 15063 eyes receiving treatment for AMD. This is a large single centre database from patients with AMD and covers more than a decade of follow-up for these patients.

Geography The Queen Elizabeth Hospital is one of the largest single-site hospitals in the United Kingdom, with 1,215 inpatient beds. Queen Elizabeth Hospital is part of one of the largest teaching trusts in England (University Hospitals Birmingham). Set within the West Midlands and it has a catchment population of circa 5.9million. The region includes a diverse ethnic, and socio-economic mix, with a higher than UK average of minority ethnic groups. It has a large number of elderly residents but is the youngest population in the UK. There are particularly high rates of diabetes, physical inactivity, obesity, and smoking.

Data source: Ophthalmology department at Queen Elizabeth Hospital, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.