The OpenSAFELY Collaborative, Tazare J, Tazare J, Walker AJ, Tomlinson L, Hickman G, Rentsch CT, Williamson EJ, Bhaskaran K, Evans D, Wing K, Mathur R, Wong AY, Schultze A, Bacon S, Bates C, Morton CE, Curtis HJ, Nightingale E, McDonald HI, Mehrkar A, Inglesby P, Davy S, MacKenna B, Cockburn J, Hulme WJ, Hulme WJ, Warren-Gash C, Bhate K, Nitsch D, Powell E, Mulick A, Forbes H, Minassian C, Croker R, Parry J, Hester F, Harper S, Eggo RM, Evans SJ, Smeeth L, Douglas IJ, Goldacre B.

Ethnic differences in COVID-19 mortality during the first two waves of the Coronavirus Pandemic: a nationwide cohort study of 29 million adults in England.

Nafilyan V, Islam N, Mathur R, Ayoubkhani D, Banerjee A, Glickman M, Humberstone B, Diamond I, Khunti K.

Sociodemographic inequality in COVID-19 vaccination coverage amongst elderly adults in England: a national linked data study

Nafilyan V, Dolby T, Razieh C, Gaughan C, Morgan J, Ayoubkhani D, Walker AS, Khunti K, Glickman M, Yates T.

Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study.

Hippisley-Cox J, Patone M, Mei XW, Saatci D, Dixon S, Khunti K, Zaccardi F, Watkinson P, Shankar-Hari M, Doidge J, Harrison DA, Griffin SJ, Sheikh A, Coupland CAC.

Obesity, Ethnicity, and Covid-19 Mortality: A population-based cohort study of 12.6 Million Adults in England

Yates T, Summerfield A, Razieh C, Banerjee A, Chudasama Y, Davies MJ, Gillies C, Islam N, Lawson C, Mirkes E, Zaccardi F, Khunti K, Nafilyan V.

Comparative effectiveness of ChAdOx1 versus BNT162b2 COVID-19 vaccines in Health and Social Care workers in England: a cohort study using OpenSAFELY

Hulme WJ, Williamson EJ, Green A, Bhaskaran K, McDonald HI, Rentsch CT, Schultze A, Tazare J, Curtis HJ, Walker AJ, Tomlinson L, Palmer T, Horne E, MacKenna B, Morton CE, Mehrkar A, Fisher L, Bacon S, Evans D, Inglesby P, Hickman G, Davy S, Ward T, Croker R, Eggo RM, Wong AY, Mathur R, Wing K, Forbes H, Grint D, Douglas IJ, Evans SJ, Smeeth L, Bates C, Cockburn J, Parry J, Hester F, Harper S, Sterne JA, Hernán M, Goldacre B.

Monitoring populations at increased risk for SARS-CoV-2 infection in the community

Pritchard E, Jones J, Vihta K, Stoesser N, Matthews PC, Eyre DW, House T, Bell JI, Newton JN, Farrar J, Crook D, Hopkins S, Cook D, Rourke E, Studley R, Diamond I, Peto T, Pouwels KB, Walker AS, the COVID-19 Infection Survey Team.

Risk of severe COVID-19 outcomes associated with immune-mediated inflammatory diseases and immune modifying therapies: a nationwide cohort study in the OpenSAFELY platform

MacKenna B, Kennedy NA, Mehkar A, Rowan A, Galloway J, Mansfield KE, Bechman K, Matthewman J, Yates M, Brown J, Schultze A, Norton S, Walker AJ, Morton CE, Harrison D, Bhaskaran K, Rentsch CT, Williamson E, Croker R, Bacon S, Hickman G, Ward T, Davy S, Green A, Fisher L, Hulme W, Bates C, Curtis HJ, Tazare J, Eggo RM, Evans D, Inglesby P, Cockburn J, McDonald HI, Tomlinson LA, Mathur R, Wong AY, Forbes H, Parry J, Hester F, Harper S, Douglas IJ, Smeeth L, Lees CW, Evans SJ, Goldacre B, Smith C, Langan SM.

Estimating the effectiveness of first dose of COVID-19 vaccine against mortality in England: a quasi-experimental study

Bermingham C, Morgan J, Ayoubkhani D, Glickman M, Islam N, Sheikh A, Sterne J, Walker AS, Nafilyan V.

SARS-CoV-2 anti-spike IgG antibody responses after second dose of ChAdOx1 or BNT162b2 and correlates of protection in the UK general population

Wei J, Pouwels KB, Stoesser N, Matthews PC, Diamond I, Studley R, Rourke E, Cook D, Bell JI, Newton JN, Farrar J, Howarth A, Marsden BD, Hoosdally S, Jones EY, Stuart DI, Crook DW, Peto TEA, Walker AS, Eyre DW, COVID-19 Infection Survey team.

Impact of Delta on viral burden and vaccine effectiveness against new SARS-CoV-2 infections in the UK

Pouwels KB, Pritchard E, Matthews PC, Stoesser N, Eyre DW, Vihta K, House T, Hay J, Bell JI, Newton JN, Farrar J, Crook D, Cook D, Rourke E, Studley R, Peto T, Diamond I, Walker AS, the COVID-19 Infection Survey Team.

Quantifying within-school SARS-CoV-2 transmission and the impact of lateral flow testing in secondary schools in England

Leng T, Hill EM, Holmes A, Southall E, Thompson RN, Tildesley MJ, Keeling MJ, Dyson L.

Symptoms and SARS-CoV-2 positivity in the general population in the UK

Vihta K, Pouwels KB, Peto T, Pritchard E, Eyre DW, House T, Gethings O, Studley R, Rourke E, Cook D, Diamond I, Crook D, Matthews PC, Stoesser N, Walker AS, the COVID-19 Infection Survey team.

Association between oral anticoagulants and COVID-19-related outcomes: a population-based cohort study.

Wong AY, Tomlinson L, Brown JP, Elson W, Walker AJ, Schultze A, Morton CE, Evans D, Inglesby P, MacKenna B, Bhaskaran K, Rentsch CT, Powell E, Williamson E, Croker R, Bacon S, Hulme W, Bates C, Curtis HJ, Mehrkar A, Cockburn J, McDonald HI, Mathur R, Wing K, Forbes H, Eggo RM, Evans SJ, Smeeth L, Goldacre B, Douglas IJ, (The OpenSAFELY Collaborative).

The impact of SARS-CoV-2 vaccines on antibody responses in the general population in the United Kingdom

Wei J, Stoesser N, Matthews PC, Studley R, Bell I, Bell JI, Newton JN, Farrar J, Diamond I, Rourke E, Howarth A, Marsden BD, Hoosdally S, Jones EY, Stuart DI, W .Crook D, Peto TEA, Pouwels KB, Eyre DW, Walker AS, COVID-19 Infection Survey team.

Impact of vaccination on new SARS-CoV-2 infections in the UK

Pritchard E, Matthews PC, Stoesser N, Eyre DW, Gethings O, Vihta K, Jones J, House T, VanSteenHouse H, Bell I, Bell JI, Newton JN, Farrar J, Diamond I, Rourke E, Studley R, Crook D, Peto T, Walker AS, Pouwels KB.

Overall and cause-specific hospitalisation and death after COVID-19 hospitalisation in England: cohort study in OpenSAFELY using linked primary care, secondary care and death registration data

Bhaskaran K, Rentsch CT, Hickman G, Hulme WJ, Schultze A, Curtis HJ, Wing K, Warren-Gash C, Tomlinson L, Bates CJ, Mathur R, MacKenna B, Mahalingasivam V, Wong A, Walker AJ, Morton CE, Grint D, Mehrkar A, Eggo RM, Inglesby P, Douglas IJ, McDonald HI, Cockburn J, Williamson EJ, Evans D, Parry J, Hester F, Harper S, Evans SJ, Bacon S, Smeeth L, Goldacre B.

Obesity, Ethnicity, and Covid-19 Mortality: A population-based cohort study of 12.6 Million Adults in England

Yates T, Summerfield A, Razieh C, Banerjee A, Chudasama Y, Davies MJ, Gillies C, Islam N, Lawson C, Mirkes E, Zaccardi F, Khunti K, Nafilyan V.

Mortality among Care Home Residents in England during the first and second waves of the COVID-19 pandemic: an analysis of 4.3 million adults over the age of 65

Schultze A, Nightingale E, Evans D, Hulme W, Rosello A, Bates C, Cockburn J, MacKenna B, Curtis HJ, Morton CE, Croker R, Bacon S, McDonald HI, Rentsch CT, Bhaskaran K, Mathur R, Tomlinson LA, Williamson EJ, Forbes H, Tazare J, Grint D, Walker AJ, Inglesby P, DeVito NJ, Mehrkar A, Hickman G, Davy S, Ward T, Fisher L, Green AC, Wing K, Wong AY, McManus R, Parry J, Hester F, Harper S, Evans SJ, Douglas IJ, Smeeth L, Eggo RM, Goldacre B, Leon DA.

Sociodemographic inequality in COVID-19 vaccination coverage amongst elderly adults in England: a national linked data study

Nafilyan V, Dolby T, Razieh C, Gaughan C, Morgan J, Ayoubkhani D, Walker AS, Khunti K, Glickman M, Yates T.

Occupation and COVID-19 mortality in England: a national linked data study of 14.3 million adults

Nafilyan V, Pawelek P, Ayoubkhani D, Rhodes S, Pembrey L, Matz M, Coleman MP, Allemani C, Windsor-Shellard B, van Tongeren M, Pearce N.

Rates of serious clinical outcomes in survivors of hospitalisation with COVID-19: a descriptive cohort study within the OpenSAFELY platform

Anti-spike antibody response to natural SARS-CoV-2 infection in the general population

Wei J, Matthews PC, Stoesser N, Maddox T, Lorenzi L, Studley R, Bell JI, Newton JN, Farrar J, Diamond I, Rourke E, Howarth A, Marsden BD, Hoosdally S, Jones EY, Stuart DI, Crook DW, Peto TEA, Pouwels KB, Walker AS, Eyre DW, the COVID-19 Infection Survey team.

Ethnicity and clinical outcomes in COVID-19: A systematic review and meta-analysis.

Sze S, Pan D, Nevill CR, Gray LJ, Martin CA, Nazareth J, Minhas JS, Divall P, Khunti K, Abrams KR, Nellums LB, Pareek M.

Association between warfarin and COVID-19-related outcomes compared with direct oral anticoagulants: population-based cohort study.

OpenSAFELY Collaborative, Wong AYS, Tomlinson LA, Brown JP, Elson W, Walker AJ, Schultze A, Morton CE, Evans D, Inglesby P, MacKenna B, Bhaskaran K, Rentsch CT, Powell E, Williamson E, Croker R, Bacon S, Hulme W, Bates C, Curtis HJ, Mehrkar A, Cockburn J, McDonald HI, Mathur R, Wing K, Forbes H, Eggo RM, Evans SJW, Smeeth L, Goldacre B, Douglas IJ.

Severity of Severe Acute Respiratory System Coronavirus 2 (SARS-CoV-2) Alpha Variant (B.1.1.7) in England.

Grint DJ, Wing K, Houlihan C, Gibbs HP, Evans SJW, Williamson E, McDonald HI, Bhaskaran K, Evans D, Walker AJ, Hickman G, Nightingale E, Schultze A, Rentsch CT, Bates C, Cockburn J, Curtis HJ, Morton CE, Bacon S, Davy S, Wong AYS, Mehrkar A, Tomlinson L, Douglas IJ, Mathur R, MacKenna B, Ingelsby P, Croker R, Parry J, Hester F, Harper S, DeVito NJ, Hulme W, Tazare J, Smeeth L, Goldacre B, Eggo RM.

Risk of Myocarditis After Sequential Doses of COVID-19 Vaccine and SARS-CoV-2 Infection by Age and Sex.

Patone M, Mei XW, Handunnetthi L, Dixon S, Zaccardi F, Shankar-Hari M, Watkinson P, Khunti K, Harnden A, Coupland CAC, Channon KM, Mills NL, Sheikh A, Hippisley-Cox J.

Risk of COVID-19 related deaths for SARS-CoV-2 Omicron (B.1.1.529) compared with Delta (B.1.617.2)

Ward IL, Bermingham C, Ayoubkhani D, Gethings OJ, Pouwels KB, Yates T, Khunti K, Hippisley-Cox J, Banerjee A, Walker AS, Nafilyan V.

Risk prediction of covid-19 related death and hospital admission in adults after covid-19 vaccination: national prospective cohort study.

Hippisley-Cox J, Coupland CA, Mehta N, Keogh RH, Diaz-Ordaz K, Khunti K, Lyons RA, Kee F, Sheikh A, Rahman S, Valabhji J, Harrison EM, Sellen P, Haq N, Semple MG, Johnson PWM, Hayward A, Nguyen-Van-Tam JS.

Risk of thrombocytopenia and thromboembolism after covid-19 vaccination and SARS-CoV-2 positive testing: self-controlled case series study.

Hippisley-Cox J, Patone M, Mei XW, Saatci D, Dixon S, Khunti K, Zaccardi F, Watkinson P, Shankar-Hari M, Doidge J, Harrison DA, Griffin SJ, Sheikh A, Coupland CAC.

Occupation and COVID-19 mortality in England: a national linked data study of 14.3 million adults.

Nafilyan V, Pawelek P, Ayoubkhani D, Rhodes S, Pembrey L, Matz M, Coleman M, Allemani C, Windsor-Shellard B, van Tongeren M, Pearce N.

Trajectory of long covid symptoms after covid-19 vaccination: community based cohort study.

Ayoubkhani D, Bermingham C, Pouwels KB, Glickman M, Nafilyan V, Zaccardi F, Khunti K, Alwan NA, Walker AS.

Short report: Ethnicity and COVID-19 death in the early part of the COVID-19 second wave in England: an analysis of OpenSAFELY data from 1<sup>st</sup> September to 9<sup>th</sup> November 2020

Bhaskaran K, Mathur R, Rentsch CT, Morton CE, Hulme WJ, Schultze A, MacKenna B, Eggo RM, Wong AY, Williamson EJ, Forbes H, Wing K, McDonald HI, Bates C, Bacon S, Walker AJ, Evans D, Inglesby P, Mehrkar A, Curtis HJ, DeVito NJ, Croker R, Drysdale H, Cockburn J, Parry J, Hester F, Harper S, Douglas IJ, Tomlinson L, Evans SJ, Grieve R, Smeeth L, Goldacre B.

Factors associated with deaths due to COVID-19 versus other causes: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform.

Bhaskaran K, Bacon S, Evans SJ, Bates CJ, Rentsch CT, MacKenna B, Tomlinson L, Walker AJ, Schultze A, Morton CE, Grint D, Mehrkar A, Eggo RM, Inglesby P, Douglas IJ, McDonald HI, Cockburn J, Williamson EJ, Evans D, Curtis HJ, Hulme WJ, Parry J, Hester F, Harper S, Spiegelhalter D, Smeeth L, Goldacre B.

Changes in the rate of cardiometabolic and pulmonary events during the COVID-19 pandemic

Walker AJ, Tazare J, Hickman G, Rentsch CT, Williamson EJ, Bhaskaran K, Evans D, Wing K, Mathur R, Wong AY, Schultze A, Bacon SC, Bates C, Morton CE, Curtis HJ, Nightingale E, McDonald HI, Mehrkar A, Inglesby P, MacKenna B, Cockburn J, Hulme WJ, Forbes H, Minassian C, Croker R, Parry J, Hester F, Harper S, Eggo RM, Evans SJ, Smeeth L, Douglas IJ, Tomlinson L, Goldacre B.

QCovid 4 - Predicting risk of death or hospitalisation from COVID-19 in adults testing positive for SARS-CoV-2 infection during the Omicron wave in England

Hippisley-Cox J, Khunti K, Sheikh A, Nguyen-Van-Tam JS, Coupland CA.

Impact of vaccination on COVID-19-associated admissions to critical care in England: a population cohort study of linked data

Harrison DA, Watkinson PJ, Doidge JC, Shankar-Hari M, Mouncey PR, Patone M, Coupland CAC, Hippisley-Cox J, Rowan KM.

Ethnicity and risks of severe COVID-19 outcomes associated with glucose-lowering medications: A cohort study.

Zaccardi F, Tan PS, Coupland C, Shah BR, Clift AK, Saatci D, Patone M, Griffin SJ, Dambha-Miller H, Khunti K, Hippisley-Cox J.

Risk of Myocarditis After Sequential Doses of COVID-19 Vaccine and SARS-CoV-2 Infection by Age and Sex.

Patone M, Mei XW, Handunnetthi L, Dixon S, Zaccardi F, Shankar-Hari M, Watkinson P, Khunti K, Harnden A, Coupland CAC, Channon KM, Mills NL, Sheikh A, Hippisley-Cox J.

Temporality of body mass index, blood tests, comorbidities and medication use as early markers for pancreatic ductal adenocarcinoma (PDAC): a nested case-control study.

Tan PS, Garriga C, Clift A, Liao W, Patone M, Coupland C, Bashford-Rogers R, Sivakumar S, Hippisley-Cox J.

Ethnic differences in the indirect impacts of the COVID-19 pandemic on clinical monitoring and hospitalisations for non-COVID conditions in England: An observational cohort study using OpenSAFELY

Costello RE, Tazare J, Piehlmaier D, Herrett E, Parker EP, Zheng B, Mansfield KE, Henderson AD, Carreira H, Bidulka P, Wong AY, Warren-Gash C, Hayes JF, Quint JK, MacKenna B, Eggo RM, Katikireddi SV, Tomlinson L, Langan SM, Mathur R, the longitudinal health and wellbeing collaborative and the OpenSAFELYcollaborative.

Changes in COVID-19-related mortality across key demographic and clinical subgroups: an observational cohort study using the OpenSAFELY platform on 18 million adults in England

The OpenSAFELY Collaborative, Nab L, Parker EP, Andrews CD, Hulme WJ, Fisher L, Morley J, Mehrkar A, MacKenna B, Inglesby P, Morton CE, Bacon SC, Hickman G, Evans D, Ward T, Smith RM, Davey S, Dillingham I, Maude S, Butler-Cole BF, O’Dwyer T, Stables CL, Bridges L, Bates C, Cockburn J, Parry J, Hester F, Harper S, Zheng B, Williamson EJ, Eggo RM, Evans S, Goldacre B, Tomlinson LA, Walker AJ.

Relative contribution of essential and non-essential activities to SARS-CoV-2 transmission following the lifting of public health restrictions in England and Wales.

Hoskins S, Beale S, Nguyen V, Boukari Y, Yavlinsky A, Kovar J, Byrne T, Fragaszy E, Fong WLE, Geismar C, Patel P, Navaratnam AMD, van Tongeren M, Johnson AM, Aldridge RW, Hayward A, Virus Watch Collaborative.

Association between smoking, e-cigarette use and severe COVID-19: a cohort study.

Gao M, Aveyard P, Lindson N, Hartmann-Boyce J, Watkinson P, Young D, Coupland C, Clift AK, Harrison D, Gould D, Pavord ID, Smith M, Hippisley-Cox J.

Exploring the relationship between job characteristics and infection: Application of a COVID-19 job exposure matrix to SARS-CoV-2 infection data in the United Kingdom.

Rhodes S, Beale S, Wilkinson J, van Veldhoven K, Basinas I, Mueller W, Oude Hengel KM, Burdorf A, Peters S, Stokholm ZA, Schlünssen V, Kolstad H, Pronk A, Pearce N, Hayward A, van Tongeren M.

A case-crossover study of the effect of vaccination on SARS-CoV-2 transmission relevant behaviours during a period of national lockdown in England and Wales.

Serisier A, Beale S, Boukari Y, Hoskins S, Nguyen V, Byrne T, Fong WLE, Fragaszy E, Geismar C, Kovar J, Yavlinsky A, Hayward A, Aldridge RW.

Evaluation of Risk Factors for Postbooster Omicron COVID-19 Deaths in England.

Nafilyan V, Ward IL, Robertson C, Sheikh A, National Core Studies—Immunology Breakthrough Consortium.

Between-Occupation Differences in Work-Related COVID-19 Mitigation Strategies over Time: Analysis of the Virus Watch Cohort in England and Wales

Beale S, Yavlinsky A, Hoskins S, Nguyen V, Byrne T, Fong WLE, Kovar J, Van Tongeren M, Aldridge RW, Hayward A.

Hospital admissions linked to SARS-CoV-2 infection in children and adolescents: cohort study of 3.2 million first ascertained infections in England.

Wilde H, Tomlinson C, Mateen BA, Selby D, Kanthimathinathan HK, Ramnarayan P, Du Pre P, Johnson M, Pathan N, Pathan N, Gonzalez-Izquierdo A, Lai AG, Gurdasani D, Pagel C, Denaxas S, Vollmer S, Brown K, CVD-COVID-UK/COVID-IMPACT consortium.

Ursodeoxycholic acid and severe COVID-19 outcomes in people with liver disease: a cohort study using the OpenSAFELY platform

Costello RE, Jean Waller KM, Smith R, Mells GF, Wong AY, Schultze A, Mahalingasivam V, Herrett E, Zheng B, Lin L, Mehrkar A, Bacon SC, Goldacre B, Tomlinson LA, Tazare J, Rentsch CT, the OpenSAFELY collaborative and the LH&W NCS (or CONVALESCENCE) Collaborative.

Effect of the 2022 COVID-19 booster vaccination campaign in 50 year olds in England: regression discontinuity analysis in OpenSAFELY

Schaffer AL, Hulme WJ, Horne E, Parker EPK, Walker V, Stables C, Mehrkar A, Bacon SC, Bates C, Goldacre B, Walker AJ, The OpenSAFELY Collaborative, Hernán MA, Sterne JAC.

Longitudinal changes in proportionate mortality due to COVID-19 by occupation in England and Wales.

Cherrie M, Rhodes S, Wilkinson J, Mueller W, Nafilyan V, Van Tongeren M, Pearce N.

Preexisting Neuropsychiatric Conditions and Associated Risk of Severe COVID-19 Infection and Other Acute Respiratory Infections.

Ranger TA, Clift AK, Patone M, Coupland CAC, Hatch R, Thomas K, Watkinson P, Hippisley-Cox J.

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