ERA Registry

ILD21

End-stage renal disease (ESRD) is a rare but severe disease in childhood. In the recent era care for children with ESRD improved dramatically. Improved neonatal intensive care and opportunities for renal replacement therapy, including renal transplantation for infants, resulted in increased survival rates. Nevertheless, transplantation in young children is challenging and requires expertise of a multidisciplinary medical team (surgeons, anaesthesiologists and paediatric nephrologists). Many centres accept a minimum recipient body weight of 10 kg, but sound evidence-based knowledge on a body weight cut-off is lacking. Therefore, our main objectives are to evaluate: (i) the current practice of kidney transplantation in young children in Europe; (ii) the association between body weight at transplantation with patient and transplant survival and; (iii) to define a minimum weight at transplantation associated with an optimal outcome for young children. Knowledge on outcome of paediatric renal transplantation in young children in relation to body weight could contribute to the development of clinical practice guidelines. Furthermore, our data could assist paediatric nephrologists to improve the treatment of children with kidney disease and could eventually lead to a lower use of dialysis, better patient and transplant survival, and better health outcomes.

18/09/2018