University of Bristol

ILD7

For children and young people whose kidneys have failed, kidney transplantation offers the best chance of normal growth and development. Transplantation also places fewer limits on patients and is the most cost-effective treatment for kidney failure. We know from studies performed in the United States (US) and Europe that certain age groups (teenagers) can be at higher risk of losing kidney transplant function although the extent of this issue is not well described across childhood and young adulthood. We wish to investigate this for young kidney transplant recipients in the UK. We also want to understand how long kidneys last for in UK children and young adults and factors that impact on their survival. The main aim of this project is to understand how long kidney transplants last in children and young adults aged <30 years (or 2-30 years at age of transplantation). We will do this by examining loss of kidney function (estimated glomerular filtration rate, eGFR) following transplant. We will also look at whether certain patient, transplant or kidney unit factors are linked to a greater fall in transplant function or loss. This will be the first study to look at changes in transplant function for all paediatric patients in the UK.

20/01/2018