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Changes in clinical parameters related to the transition from dialysis to kidney transplantation

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Organisation name

ERA Registry

Safe Projects

Project ID

ILD16

Lay summary

Kidney transplantation is the preferred treatment for end-stage kidney disease because it reverses many complications of chronic kidney disease, improves the quality of life and prolongs patient survival. However, most end stage kidney disease patients are treated with dialysis before receiving a kidney transplant. Dialysis commonly results in conditions such as anaemia, disturbed mineral metabolism and abnormally high levels of fats in the blood. Kidney transplantation should correct or improve many of these conditions, but its exact impact is incompletely understood. With this study we aim to assess to what extent the transition from dialysis treatment to kidney transplantation is related to changes in mineral metabolism, iron status, lipid (fat) profile and inflammatory status. If we can show that conditions such as anaemia, disordered mineral metabolism and high levels of fat in the blood improve (soon) after kidney transplantation, the findings of this study could strengthen the evidence supporting the importance of receiving a kidney transplant. This may further increase awareness among policy makers and increase initiatives that promote kidney transplantation. The study results will increase the understanding of physiological changes in kidney transplant recipients and could help to adjust the treatment strategy in these patients. Furthermore, the results of this study may provide some information on the prognosis of patients who receive a kidney transplant.

Latest approval date

22/03/2018

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Dataset(s) name