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Understanding the relationship between symptom burden and quality of life in chronic kidney disease: a UK cohort study in 3,325 patients
Safe People
University of Manchester
Safe Projects
ILD32
The symptom burden in people with chronic kidney disease is high, which negatively affects their quality of life. In most cases, people suffer from multiple symptoms at the same time, such as fatigue, sleep disturbance, pain and itch. Treatment strategies that address clusters of symptoms may therefore be more effective in improving quality of life than those focusing on single symptoms. However, evidence to inform such strategies is currently scarce. For this study, we will retrospectively analyse responses to the Your Health survey that are currently available in the UK Renal Registry, with a focus on symptoms and quality of life. This will be the largest cohort study to date to investigate symptom burden in chronic kidney disease patients across disease stages and treatment modalities. It will provide a robust external validation of symptom clusters and their association with quality of life. The study findings will also inform how symptom data can best be presented to patients and their renal teams to aid interpretation and decision making. For example, by generating a notification if the symptom burden crosses a certain ‘tipping point’. Ultimately, this will contribute to improving symptom management and quality of life.
28/03/2019