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COVID19RENAL: The Impact of COVID19 on Renal and Immunosuppressed Patients

Safe People

Organisation name

Imperial College London

Organisation sector

Academic Institute

Applicant name(s)

Dr Michelle Willicombe

Safe Projects

Project ID

DISCOVERNOW6

Lay summary

COVID19 is a novel coronavirus currently at the centre of a global pandemic. From the cases we have seen in China and Italy, it appears that the people most at risk of a serious complication, hospitalisation and death are elderly patients and patients who have other co-existing medical conditions. Many patients with renal disease fall into the high risk category as they may be on dialysis (a form of renal replacement therapy) or they may have a renal transplant and be taking medication which suppresses their immune system. In either case, renal patients can often find it harder to fight infections and they are more at risk of developing complications from viral infections. In our study, we aim to collect information on how COVID19 affects patients with renal disease, alongside morbidity and mortality data. We will also look at blood results, importantly markers of infection and inflammation. COVID19 can present with a range of symptoms from mild to severe, with some people even having no symptoms at all. Immunosuppressed patients are theoretically at increased risk of severe disease, although data on outcome of such patients is scarce. Whether immunosuppressed patients can too have asymptomatic disease is not known. Understanding if immunity can and has developed in patients on immunosuppression will help identify those patients at continued risk. We aim to analyse the incidence of immunity in immunosuppressed patients by measuring antibody (proteins that fight infection) levels using a novel COVID-19 IgM-IgG Rapid Test . If immunity is identified in asymptomatic patients, this would support more widespread testing for patients to help plan their management during the COVID19 pandemic.

Latest approval date

15/05/2020

Safe Data

Dataset(s) name

ICHNT -COVID-19