University of Manchester

Academic Institute

No

CCU068

Congenital heart disease (CHD) is the commonest birth defect, affecting just under 1% of the population – at least 700,000 people in the UK. Work we have done in UK general practice patients, using information predating mass COVID vaccination, has shown that patients with CHD who become infected with COVID-19 are at a greater risk of being admitted to hospital and of death. Our previous analysis also found that the presence of conditions that may complicate CHD, such as increased blood pressure in the lungs, further increase those risks. It is not known how vaccination helps reduce these risks in CHD patients or which related conditions might still pose an increased risk. The BHF Data Science Centre holds the up-to-date data regarding patient vaccination as well as other medical records allowing us to determine COVID-related risk in CHD patients. We will evaluate various types of heart defects, along with associated medical conditions, to determine if vaccination takes away the additional risk we have previously found.

The proposed study will inform health policy regarding the clinical management of CHD patients in terms of COVID-19 and their vaccination. In addition, it will potentially highlight other medical conditions associated with CHD that may require monitoring and future clinical care. Visit the BHF Data Science Centre website for more detailed information about project outputs. https://bhfdatasciencecentre.org/projects/ccu068/

This project accessed the following datasets within the Trusted Research Environment(s) for CVD-COVID-UK / COVID-IMPACT: - ENGLAND: - Civil Registration - Deaths - COVID-19 SARI-Watch (formerly CHESS) - Covid-19 Second Generation Surveillance System - Covid-19 UK Non-hospital Antibody Testing Results - Covid-19 UK Non-hospital Antigen Testing Results - COVID-19 Vaccination Status - Emergency Care Data Set (ECDS) - GPES Data for Pandemic Planning and Research (COVID-19) - Hospital Episode Statistics Admitted Patient Care - Hospital Episode Statistics Critical Care - Hospital Episode Statistics Outpatients - ICNARC: Intensive Care National Audit and Research Centre - Medicines dispensed in Primary Care (NHSBSA data) - NICOR – NCHDA: National Congenital Heart Disease Audit - Secondary Care Prescribed Medicines (EPMA) - Secondary Uses Services Payment By Results - Uncurated Low Latency Hospital Data (Admitted Patient Care, Outpatients, Critical Care) - WALES: - Annual District Death Daily (ADDD) - Annual District Death Extract (ADDE) - Congenital Anomaly Register and Information Service (CARS) - Covid Vaccination Dataset (CVVD) - COVID-19 Consolidated Deaths (CDDS) - COVID-19 Shielded People List (CVSP) - COVID-19 Test Results (PATD) - COVID-19 Test Trace and Protect (CTTP) - Legacy - Critical Care Dataset (CCDS) - Emergency Department Dataset (EDDS) - Emergency Department Dataset Daily (EDDD) - Intensive Care National Audit and Research Centre (ICCD) - Legacy - COVID only - Intensive Care National Audit and Research Centre (ICNC) - Outpatient Database for Wales (OPDW) - Patient Episode Dataset for Wales (PEDW) - SARS-CoV-2 viral sequencing data (COG-UK data)-Lineage/Variant Data-Wales (CVSD) - Welsh Demographic Service Dataset (WDSD) - Welsh Longitudinal General Practice Dataset (WLGP) - Welsh Primary Care - Welsh Longitudinal GP Dataset - Welsh Primary Care (Daily COVID codes only) (GPCD)

29/06/2023

De-Personalised

TRE