Bookmarks
CCU076: The effect of COVID-19 infection on cardiovascular outcomes: an interaction analysis with environmental exposure
Safe People
Organisation name
University of Cambridge,University of Bristol
Organisation sector
Academic Institute
Applicant name(s)
Elena Raffetti
Angela Wood
Rachel Denholm
Sub-licence arrangements (if any)?
No
Safe Projects
Project ID
CCU076
Lay summary
COVID-19 infection may become an annual winter virus and follow a clear seasonal pattern, like influenza. Environmental factors, such as extremes in temperature and pollution, could make it easier for the COVID-19 infection to increase the chances of getting a severe case of the virus. This has consequences for cardiovascular risk, as both COVID-19 infection and such environmental factors are known to increase the occurrence of cardiovascular events. However, no study has yet examined the combined effect of both COVID-19 infection and air temperature/pollution on cardiovascular risk. Our research aims to quantify how environmental factors, specifically air temperature and pollution levels, interact with COVID-19 and affect cardiovascular outcomes like heart attacks and strokes. We will also examine whether this interaction is higher in individuals with pre-existing heart conditions.
Public benefit statement
The findings from our research will offer valuable insights for the public, policy makers and healthcare providers. It will help identify who is at greatest risk of severe cardiovascular outcomes due to environmental factors and COVID-19 infection. This information can help us take specific actions to prevent problems. By helping to identify those at highest risk, our results will support more informed decision-making and inform planning and resource allocation for healthcare services. Global climate change underlines the importance of such research. Visit the BHF Data Science Centre website for more detailed information about project outputs. https://bhfdatasciencecentre.org/projects/ccu076/
Technical summary
This project accessed the following datasets within the Trusted Research Environment(s) for CVD-COVID-UK / COVID-IMPACT: - ENGLAND: - Civil Registration - Deaths - COVID-19 SARI-Watch (formerly CHESS) - Covid-19 Second Generation Surveillance System - Covid-19 UK Non-hospital Antibody Testing Results - Covid-19 UK Non-hospital Antigen Testing Results - COVID-19 Vaccination Adverse Reaction - COVID-19 Vaccination Status - GPES Data for Pandemic Planning and Research (COVID-19) - Hospital Episode Statistics Accident and Emergency - Hospital Episode Statistics Admitted Patient Care - Hospital Episode Statistics Critical Care - Hospital Episode Statistics Outpatients - ICNARC: Intensive Care National Audit and Research Centre - Medicines dispensed in Primary Care (NHSBSA data) - NICOR – MINAP: Myocardial Ischaemia National Audit Project - NICOR – NACRM: National Audit of Cardiac Rhythm Management - NICOR – NACSA: National Adult Cardiac Surgery Audit - NICOR – NCHDA: National Congenital Heart Disease Audit - NICOR – NHFA: National Heart Failure Audit - NICOR – PCI: Percutaneous Coronary Interventions - NICOR – TAVI: Transcatheter Aortic Valve Implantation - Secondary Care Prescribed Medicines (EPMA) - Secondary Uses Services Payment By Results - Sentinel Stroke National Audit Programme Clinical Dataset
Latest approval date
20/11/2023
Safe Data
Dataset(s) name
Data sensitivity level
De-Personalised
Safe Setting
Access type
TRE