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Delirium as an acute brain injury in hospital inpatients: can clinical features and biomarkers predict outcomes?
Safe People
Organisation name
University of Edinburgh
Applicant name(s)
Professor Alasdair MacLullich with Miss Temi Ibitoye
Funders/ Sponsors
MRC
Safe Projects
Project ID
DL-2021-042
Lay summary
Delirium is a sudden-onset serious disturbance in mental abilities that affects 1 in 4 older hospitalised patients. It is highly distressing for patients and carers. The cause of delirium is unknown but delirium is associated with poor health events such as a higher risk of dying, staying long in hospital or future mental health decline. This suggests that delirium may be a marker of brain health and dementia risk. However, there are no large-scale studies which have explored possible clinical indicators of delirium and their relationship with poor health events. Clinical indicators include blood tests or body measurements such as blood pressure and oxygen levels. This project will identify clinical markers that are important in people with delirium and how these are related to poor health events. Research in this area will contribute to our knowledge of delirium and may improve how it is identified and managed in hospitals.
Request category type
Public Health Research
Latest approval date
06/09/2022
Safe Data
Dataset(s) name
Data sensitivity level
De-Personalised
Safe Setting
Access type
TRE