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CCU005: Data management and analysis methods
Safe People
Organisation name
University of Cambridge
Organisation sector
Academic Institute
Applicant name(s)
Angela Wood
Sub-licence arrangements (if any)?
No
Safe Projects
Project ID
CCU005
Lay summary
Since the COVID-19 pandemic, there has been rapid progress made towards the availability and accessibility of national healthcare data for research. Consequently, for the first time we are analysing data from over 65 million patients across the UK to help us understand more about COVID-19. Our analyses have the advantages of being able to study individuals with and without different health-related problems across all age groups, ethnicities, geographies and socioeconomic settings. Our results will be directly relevant to everyone living in the UK. However, there are a number of challenges and limitations to using routinely collected healthcare data for research. The problems mainly arise because electronic health records are designed for clinical purposes, and do not necessary provide an accurate picture of the true health status on all patients at all times. If we do not address these problems properly in the analysis, then we will get biased results and make incorrect conclusions. We aim to identify and provide solutions to address the challenges and limitations in the analysis of population-wide healthcare data. Ultimately, we want to ensure results arising from population-data healthcare data are accurately reported.
Public benefit statement
We aim to identify and provide solutions to address the challenges and limitations in the analysis of population-wide healthcare data. Ultimately, we want to ensure results arising from population-data healthcare data are accurately reported. Visit the BHF Data Science Centre website for more detailed information about project outputs. https://bhfdatasciencecentre.org/projects/ccu005/
Technical summary
This project accessed the following datasets within the Trusted Research Environment(s) for CVD-COVID-UK / COVID-IMPACT: - ENGLAND: - Civil Registration - Deaths - COVID-19 SARI-Watch (formerly CHESS) - Covid-19 Second Generation Surveillance System - Covid-19 UK Non-hospital Antibody Testing Results - Covid-19 UK Non-hospital Antigen Testing Results - COVID-19 Vaccination Adverse Reaction - COVID-19 Vaccination Status - Emergency Care Data Set (ECDS) - GPES Data for Pandemic Planning and Research (COVID-19) - Hospital Episode Statistics Accident and Emergency - Hospital Episode Statistics Admitted Patient Care - Hospital Episode Statistics Critical Care - Hospital Episode Statistics Outpatients - ICNARC: Intensive Care National Audit and Research Centre - Improving Access to Psychological Therapies Data Set - Medicines dispensed in Primary Care (NHSBSA data) - Mental Health Services Data Set - MSDS (Maternity Services Data Set) - NICOR – MINAP: Myocardial Ischaemia National Audit Project - NICOR – NACRM: National Audit of Cardiac Rhythm Management - NICOR – NACSA: National Adult Cardiac Surgery Audit - NICOR – NCHDA: National Congenital Heart Disease Audit - NICOR – NHFA: National Heart Failure Audit - NICOR – PCI: Percutaneous Coronary Interventions - NICOR – TAVI: Transcatheter Aortic Valve Implantation - Secondary Care Prescribed Medicines (EPMA) - Secondary Uses Services Payment By Results - Sentinel Stroke National Audit Programme Clinical Dataset - Uncurated Low Latency Hospital Data (Admitted Patient Care, Outpatients, Critical Care) - SCOTLAND: - COVID Tests - Diabetes covariates - General Acute Inpatient and Day Case - Scottish Morbidity Record (SMR01) - National Records of Scotland (NRS) - Deaths Data - NHS Scotland General Practice (GP) Contact Data - Subset - Outpatient Appointments and Attendances - Scottish Morbidity Record (SMR00) - Prescribing Information System (PIS) - SARS-CoV-2 viral sequencing data (COG-UK data) - Lineage/Variant Data - Scotland - Scotland Accident and Emergency - Scottish Covid-19 Vaccination Data - Scottish Renal Registry - Scottish Stroke Care Audit - SICSAG Daily (Scottish Intensive Care Audit Group) - SICSAG Episodes (Scottish Intensive Care Audit Group) - WALES: - Annual District Birth Extract (ADBE) - Annual District Death Daily (ADDD) - Annual District Death Extract (ADDE) - Care Home Dataset (CARE) - Congenital Anomaly Register and Information Service (CARS) - Covid Vaccination Dataset (CVVD) - COVID-19 Consolidated Deaths (CDDS) - COVID-19 Shielded People List (CVSP) - COVID-19 Test Results (PATD) - COVID-19 Test Trace and Protect (CTTP) - Legacy - Critical Care Dataset (CCDS) - Emergency Department Dataset (EDDS) - Emergency Department Dataset Daily (EDDD) - Intensive Care National Audit and Research Centre (ICCD) - Legacy - COVID only - Intensive Care National Audit and Research Centre (ICNC) - Maternity Indicators Dataset (MIDS) - National Community Child Health Database (NCCHD) - Outpatient Database for Wales (OPDW) - Outpatient Referral (OPRD) - Patient Episode Dataset for Wales (PEDW) - Referral to Treatment Times (RTTD) - SAIL Dementia e-Cohort (SDEC) - SARS-CoV-2 viral sequencing data (COG-UK data)-Lineage/Variant Data-Wales (CVSD) - Welsh Ambulance Services NHS Trust (WASD) - Welsh Demographic Service Dataset (WDSD) - Welsh Dispensing Dataset (WDDS) - Legacy - Welsh Longitudinal General Practice Dataset (WLGP) - Welsh Primary Care - Welsh Longitudinal GP Dataset - Welsh Primary Care (Daily COVID codes only) (GPCD) - Welsh Results Reports Service (WRRS)
Latest approval date
30/10/2020
Safe Data
Dataset(s) name
Data sensitivity level
De-Personalised
Safe Setting
Access type
TRE
Safe Outputs
Link to research outputs