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CCU079: Investigating the diagnoses of conditions among children in England following SARS-CoV-2 infections compared to general respiratory infections

Safe People

Organisation name

University of Bristol

Organisation sector

3

Applicant name(s)

Katharine LookerEleanor Walsh

Funders/ Sponsors

Safe Projects

Project ID

CCU079

Lay summary

COVID-19 infection (also known as Covid, or severe acute respiratory syndrome coronavirus 2 infection) is mostly mild in children and young people. When someone continues to have symptoms weeks after their COVID-19 infection, this is known as long-COVID. Previous studies, and an online discussion group with families affected by long-COVID, have shown that these long-lasting symptoms are wide-ranging and can be severe. Some children and young people develop a new condition since having long-COVID. At the moment we don’t know: • How many children and young people with COVID-19 infection go on to develop long-COVID. • Which new diagnoses of other conditions (such as heart conditions, or problems with breathing) are associated with long-COVID. • Which groups of children and young people have the highest risk of developing long-COVID and associated conditions. We are now in the UK Government’s “Living with COVID” phase, which means much less testing for COVID-19 infection is happening. Instead, doctors assess patients solely on the basis of symptoms such as fever. However, many different infections can cause similar symptoms to COVID-19, and they too can have lingering health effects. We would like to find out in what ways the healthcare needs for long-COVID in children and young people are different to those for long-term health effects from other infections. This research will tell us which diagnoses children and young people with COVID-19 infection may go on to have. It will also tell us what makes some children more likely to develop these conditions compared to other children (e.g., older children, or those with pre-existing illnesses like asthma). Finally, we will compare our findings to those for long-term effects of other infections, to see in what ways long-COVID is different. We will use health record data for school-aged children (4-18 years) for the whole of England to carry out our research.

Public benefit statement

The results of this study will help us know which diagnoses children and young people have following COVID-19 infection, how many children and young people are affected, and what made them more likely to develop these conditions. If we know these things, we can plan healthcare services better. Doctors will have more information to help answer the questions families have about long-COVID. They will also be able to have more informed conversations with families and offer better care and advice to children and young people who have, or who are more likely to get, long-COVID.

Other approval committees

Project start date

03/03/2024

Project end date

02/08/2027

Latest approval date

01/03/2024

Safe Data

Dataset(s) name

GPES Data for Pandemic Planning and Research (COVID-19)

Hospital Episode Statistics Admitted Patient Care

Hospital Episode Statistics Critical Care

Hospital Episode Statistics Outpatients

Hospital Episode Statistics Accident and Emergency

Emergency Care Data Set (ECDS)

Covid-19 Second Generation Surveillance System

Covid-19 UK Non-hospital Antigen Testing Results

COVID-19 Vaccination Status

Civil Registration - Deaths

Trusted Research Environments for CVD-COVID-UK / COVID-IMPACT

Data sensitivity level

De-Personalised

Release/Access date

01/03/2024

Safe Setting

Access type

TRE

Safe Outputs

Link to research outputs