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CCU084: Impact of COVID-19 on stroke incidence, severity, aetiology, management and outcome in younger vs. older individuals in England

Safe People

Organisation name

University of Oxford

Organisation sector

3

Applicant name(s)

Linxin Li

Funders/ Sponsors

Safe Projects

Project ID

CCU084

Lay summary

Each year, the number of new strokes diagnosed in older people has been decreasing. However, even before COVID-19 hit, the number of strokes in people aged under 55 had doubled in the last 10 years. Researchers found that both getting COVID-19 and certain types of vaccines are linked to a higher risk of stroke, especially in younger people. And this increased risk can last for at least a year. These findings suggest that the trend of more strokes in younger people might be getting worse. This project aims to test this idea and gather new information to help prevent strokes in younger people in the time after COVID-19. There are three main aims: 1. We want to understand how many new strokes happen each year before, during and after the COVID-19 pandemic, looking at factors like age, gender, ethnicity, socioeconomic status, and where they live. By doing this, we can work out which groups are most affected by strokes and make sure we focus our efforts and resources where they are needed most. 2. We want to work out why the trend of more strokes in younger people might be worsening. We will look into whether there were problems with the diagnosis and management stroke risk factors during and after the pandemic. This will help us to focus our efforts on preventing strokes in younger people. 3. We will look at whether there were more or fewer treatments for strokes in young people during and after the COVID pandemic. This will help us see if a particular important guideline, which came out just before COVID-19, is being followed.

Public benefit statement

The findings from this research could provide new and widely applicable information about how strokes are affecting younger people before, during, and after the COVID-19 pandemic. This will guide the NHS and policymakers in deciding where to focus resources.

Other approval committees

Project start date

03/05/2024

Project end date

02/04/2025

Latest approval date

09/06/2024

Safe Data

Dataset(s) name

GPES Data for Pandemic Planning and Research (COVID-19)

Hospital Episode Statistics Admitted Patient Care

Hospital Episode Statistics Accident and Emergency

Emergency Care Data Set (ECDS)

Covid-19 Second Generation Surveillance System

COVID-19 Vaccination Status

COVID-19 Vaccination Adverse Reaction

Civil Registration - Deaths

Medicines dispensed in Primary Care (NHSBSA data)

Sentinel Stroke National Audit Programme Clinical Dataset

Trusted Research Environments for CVD-COVID-UK / COVID-IMPACT

Data sensitivity level

De-Personalised

Release/Access date

09/06/2024

Safe Setting

Access type

TRE

Safe Outputs

Link to research outputs