Roche

2

Satu Nahkuri

OFHS240113

This study aims to improve how Roche develops medicines and tests for diseases. Our genes can affect our health, including how we heal and how we respond to medications. By examining large amounts of health information and genetic data from Our Future Health, we seek to identify genes that point to new treatments. We also want to understand why people respond differently to medicines, so that we can better match the right medicine to the right patient at the right time. In the long term, this could mean faster and more effective care for patients, especially those with conditions like cardiovascular disease, Alzheimer's, or cancer, where finding the right treatment can be difficult. Ultimately, our research can lead to better, more personalized treatments for diseases that don't have good treatment options yet. At Roche, we use genetic and healthcare data to help develop new drugs and diagnostic tools. This data shows how changes in genes can affect health, which helps us predict how our treatments might work. Research shows that drug projects supported by genetic data are more likely to succeed. We work on many different diseases, so we use a wide range of data to identify unmet patient needs, find new treatment opportunities, predict safety issues, and improve early disease detection. We get our genetic data from various sources, including our own clinical trials, collaborations, and published research. Increasingly, we rely on large biobanks like the UK Biobank and FinnGen, which collect extensive health and genetic information. These biobanks have limitations, but they provide valuable insights. The new biobank built by Our Future Health will be crucial as it includes a large, diverse group of participants and detailed, long-term health data. This gives us a clearer picture of the patient journey and how illnesses develop and change over time. In the future, we expect to be able to contact participants for further studies. Our Future Health will help us discover new drug targets, understand how diseases progress, and develop better diagnostic tools.

The research we hope to undertake will have multiple benefits for public health. First, this research will transform our ability to develop new medicines to treat or prevent diseases for which current treatment options are limited. Second, we will use this research to develop new ways of testing for the earliest stages of disease. Third, we will use this research to understand how we can become better at getting the right treatments to the right patients at the right time. We expect the treatments and tests that arise from this research to offer new chances to treat and prevent the most important diseases. These include cancer, dementia and diabetes. Research within Our Future Health will help us to accelerate the delivery of safe and effective medicines to patients.

Public Health Research

23/08/2024

16/08/2024

TRE