King's College London

ILD40

About one in three women with severe kidney disease have permanent damage to their kidneys during or after pregnancy and may need dialysis to survive. Having dialysis is extremely challenging for a new mother and her life expectancy will be shortened. Women with severe kidney disease may also experience adverse pregnancy outcomes such as their baby being born early or small. Women with less severe kidney disease are also more likely to have pregnancy complications. There is currently no reliable way to work out which women with kidney disease are likely to have pregnancy-associated disease progression or experience adverse pregnancy outcomes. We plan to develop an online calculator which can predict the individualised risk of pregnancy-associated kidney progression and adverse pregnancy outcomes for women with pre-existing kidney disease. Data from the UKRR (500 Renal replacement therapy patients) will contribute to the development of the prediction tool and ensure that it is developed on a representative cohort with kidney disease of all severities. The study will allow us to provide accurate information for women who are considering a pregnancy including those with rarer renal disease. The data will help them to understand how likely it is that they will have a deterioration in their kidney function, or have adverse pregnancy outcomes.