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COVID-19 testing and infection among English children and young adults with advanced chronic kidney disease using Public Health England and UK Renal Registry linked data.

Safe People

Organisation name

University of Bristol and UK Renal Registry

Applicant name(s)

Funders/ Sponsors

Safe Projects

Project ID

ILD87

Lay summary

SARS-CoV-2 infection (also known as COVID-19) was identified in late 2019 and has led to a worldwide pandemic. Current evidence shows that children are at very low risk of severe infection and death from COVID-19. In July 2020, the UK Renal Registry published a letter in the Archives of Diseases in Childhood to highlight that only 5 cases of COVID-19 infection in children with chronic kidney disease had been reported across the UK. There is limited information available on the characteristics of children and young adults with advanced chronic kidney disease who go on to develop COVID-19 infection. As rates of COVID-19 infection in children are low, nationally-representative populations are needed to identify sufficient case numbers, which will allow us to look at patient characteristics in greater detail and may help determine who is at greatest risk of infection. This report will use UK Renal Registry (UKRR) – Public Heath England linked data to identify the numbers of children and young adults with chronic kidney disease in England who were confirmed to have COVID-19 infection. Key patient features for these cases will also be identified. The study will include two groups of patients: children aged under 18 years with CKD stages 4 or 5, or with kidney failure requiring kidney replacement therapy (KRT) and the same for young adults aged between 18 and 30 years. The study period will be from 26th March to the date of the last Public Health England linkage (September 2020). We expect approximately 4500 patients to be included in the studied cohort, of whom approximately 30-50 will have had a confirmed COVID-19 infection. This study will be the first to report the number of children and young adults across England with chronic kidney disease who have had confirmed COVID-19 infection, and to describe their clinical features. We will be able to explore whether the infected cohort differ from the total cohort which will shed light on potential risk factors for infection within this group. We will also identify deaths from COVID-19 infection in this group and where possible, will identify characteristics associated with risk of death.

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Safe Data

Dataset(s) name