London School of Hygiene & Tropical Medicine

ILD92

Acute kidney injury (AKI) is a sudden decrease in kidney function over a short period of time. Though once thought as fully reversible, AKI episodes are now associated with worsened outcomes. More severe AKI is also associated with higher risk of mortality as well as subsequent need of dialysis, indicating progression from reversible to irreversible kidney injury. In addition, longer AKI episodes and recurrent AKI are both associated with poorer clinical outcomes, though there is less research into this. These results also imply significant socioeconomic costs. Learning more about AKI-associated outcomes and their predictors is crucial. Understanding helps better-inform policy-making decisions so they are able to better support patient care. We will use UK Renal Registry (UKRR) data to investigate AKI and its associated outcomes. We will include all adult and paediatric patients in the datasets. There is little research into the independent association between AKI duration and short-term mortality as well as long-term dialysis. This project aims to investigate this association and whether it varies by hospital clusters, seasonality, and age (paediatric/adult). Unlike previous studies which focus on the association between AKI and short-/long-term adverse events in patients with specific comorbidities (e.g. concurrent cardiovascular diseases), results from this project will be generalisable on a national scale. They will provide insight to guide better patient-care and resource allocation to different hospitals.