ERA Registry

ILD94

The survival of paediatric patients with cancer has improved significantly during recent decades. Problems with kidney function is a relatively common problem in cancer patients. Only a few single center reports about kidney replacement therapy (KRT) in paediatric cancer patients are available. It is important to evaluate trends in the incidence, presence of co-morbidities, and outcome in paediatric patients who started KRT after (or due to) cancer treatment and compare these to patients without a history of cancer. This study will use UK Renal Registry (UKRR) data to evaluate the graft and patient survival, growth, prevalence of hypertension, and secondary malignancies and cancer relapses in paediatric kidney transplant recipients who had a history of cancer before receiving KRT. We will then compare the outcomes with patients receiving KRT without cancer history. All patients with a history of cancer before the initiation of KRT will be identified from the ESPN/ERA-EDTA Registry. Our main objective is to evaluate access to transplantation and patient and graft survival in paediatric patients who started KRT after (or due to) cancer treatment. Secondary objectives are to evaluate the risk of secondary malignancies after initiation of KRT, and to compare the prevalence of hypertension and growth failure among children with and without a history of cancer before KRT. We also aim to report long-term outcomes of paediatric KRT patients who have had cancer before starting kidney replacement therapy. This study is expected to provide novel information which can be used in clinical practice.