Southampton Children’s Hospital

ILD115

Acute kidney injury (AKI) is characterised by a sudden decline in kidney function. AKI occurs in 5% of all non-critically ill children and in over 25% of critically ill patients. AKI is associated with poorer in-hospital short-term outcomes. In the longer term, proteinuria, hypertension and chronic kidney disease (CKD) are more prevalent among children who had previously sustained AKI compared to the general population. Kidney failure is one of the severe long-term complications of AKI, and there is very little published data in children. This will be one of the first UK reports to describe the requirement of kidney replacement therapy (KRT) after AKI in children. We will use UK Renal Registry data to identify children under 16 who had experienced AKI between 2016-2019, and those who subsequently go on to require long-term (>90 days) kidney replacement therapy (KRT). We will also describe and compare the demographic and clinical characteristics between those who required and those who did not require KRT, including the number and severity of AKI as well as relevant variables during their hospital stays. Findings from the study will enable clinicians to learn more about the relationship between AKI and kidney failure. By understanding the risk factors for kidney failure in the context of AKI, clinicians will be able to identify patients who are at higher risk of worse outcomes and develop preventative strategies.