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AKI Episodes in paediatric renal transplant patients

Safe People

Organisation name

Great Ormond Street Hospital for Children

Applicant name(s)

Funders/ Sponsors

Safe Projects

Project ID

ILD120

Lay summary

Acute Kidney injury (AKI) is characterised by a sudden decline in kidney function. AKI is a common reason for loss of kidney transplant function and children with kidney transplants are more at risk of developing AKI than the general population. A single centre study in Canada looked at 122 children which showed AKI was strongly associated with lower kidney function. In the UK, a single centre study in children with chronic kidney disease (CKD) showed that AKI was associated with a decline in kidney function. Currently there is little published data describing AKI in the UK paediatric kidney transplant population. This study will help to understand what demographic factors are present in paediatric kidney transplant patients who present with AKI and help identify which paediatric renal transplant recipients are most at risk of developing AKI. We will use UK Renal Registry data to identify all paediatric (<18 years of age) kidney transplant recipients who received an AKI alert between 01/01/2015 - 31/12/2020 and describe their demographic factors. These patients will also be cross referenced with Hospital Episode Statistics to describe details of any hospital admissions. We plan to follow children from time of first AKI episode until end of study period (31/12/2020) thus the period of follow-up will be between 0 and 5 years.

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Safe Data

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