University of Oxford

Academic Institute

Valeria Frighi - Chief Investigator - University of OxfordValeria Frighi - Corresponding Applicant - University of OxfordFelix Achana - Collaborator - University of OxfordGary Collins - Collaborator - University of OxfordJan Blair - Collaborator - Dimensions (UK) LtdMargaret Smith - Collaborator - University of OxfordMay Ee Png - Collaborator - University of OxfordStavros Petrou - Collaborator - University of OxfordTim Holt - Collaborator - University of OxfordTimothy Andrews - Collaborator - Oxford Health NHS Foundation Trust

CPRD06

Our previous study (ISAC Protocol 18_186R) based on CPRD Gold and linked databases showed that people with intellectual disabilities (ID) are at markedly higher risk of fractures, particularly of the hip, than age and sex matched people without ID. These are devastating events, which can cause persistent disability for the individual, and high health and social care costs. Such fractures are often preventable, being largely due to osteoporosis (thinning of the bones), a very treatable condition. People with ID do not generally have their fracture risk assessed, and when they do, standard scores underestimate their risk, hence opportunities for prevention are missed. Therefore, we developed a new score for assessing fracture risk, IDFracture, specifically tailored to these patients.

Unpublished results from our previous study (ISAC Protocol 18_186R) in CPRD Gold linked to HES show higher incidence of major osteoporotic (MOP) fractures (vertebra, shoulder, wrist, hip) and of hip fracture in adults with intellectual disabilities [ID] (n= 27706) compared to age and sex matched adults without ID (n= 139033).

09/06/2021

Release