Boehringer Ingelheim

Commercial

Smit Patel - Chief Investigator - Boehringer-Ingelheim International GmbHChristopher Griffiths - Collaborator - University of ManchesterDarren Ashcroft - Collaborator - University of ManchesterRichard warren - Collaborator - University of Manchester

CPRD13

Pustular psoriasis, is a rare form of psoriasis, that is characterised by widespread pustules (white, pus-filled, painful bumps) on a background of red and tender skin. There are different types of pustular psoriasis that depend on where the symptoms appear: Palmoplantar pustulosis (PPP) is when pustules appear on the palms of the hand and/or soles of the feet. Generalised pustular psoriasis (GPP) describes pustules that affect large areas of the body. Patients with GPP often develop symptoms beyond the skin, such as fever, chills and fatigue, which can lead to serious complications, and even death. Due to the rareness of PPP and GPP, literature is limited. The number of individuals in the UK affected by these conditions are unknown. There are also no studies reporting the extent of healthcare utilisation in the UK, and no recent studies investigating the death rates of these patients.

Generalised pustular psoriasis (GPP) and palmoplantar pustulosis (PPP) are two sub-classifications of pustular psoriasis. GPP is characterised by rapidly progressing diffuse erythematous patches with pustules that coalesce to form lakes of pus. Patients with GPP may experience flares which can lead to serious complications such as sepsis, and even death. In PPP, pustules are restricted to the palms of hands and soles of feet. Both GPP and PPP can occur independently of a history of psoriasis.

27/05/2021

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