University of Leicester

Academic Institute

G. Andre Ng - Chief Investigator - University of LeicesterTom Norris - Corresponding Applicant - University of LeicesterAkash Mavilakandy - Collaborator - University of LeicesterBharat Sidhu - Collaborator - University of LeicesterClare Gillies - Collaborator - University of LeicesterFrancesco Zaccardi - Collaborator - University of LeicesterKamlesh Khunti - Collaborator - University of LeicesterNilesh Samani - Collaborator - University of LeicesterZakariyya Vali - Collaborator - University of Leicester

CPRD39

Atrial Fibrillation (AF) is the most common heart rhythm disturbance seen in clinical practice. AF increases the risk of stroke five-fold and is associated with increased risk of heart failure and mortality. Early detection, diagnosis and treatment of AF with oral anti-coagulation can help reduce the incidence of potentially devastating strokes. In the South Asian population there is a high rate of stroke and transient ischaemia attacks (also known as 'mini strokes'), however, it has been reported that the prevalence of AF is significantly lower compared to Caucasians. Paradoxically South Asians have a greater prevalence of cardiovascular risk factors such as hypertension, diabetes and coronary artery disease, traditionally associated with the development of AF. The reasons for this are not understood and have not been fully researched. South Asians have not been well represented in large clinical trials. Therefore, investigating this paradox would lead to better understanding of the ethnic differences in the aetiologies of both stroke and AF, and the interaction between these two diseases.

Atrial Fibrillation (AF) is the most common arrhythmia seen in clinical practice, affecting approximately 1.4 million people in the UK.[1] AF is a major causative factor for ischaemic stroke.[2] Identifying patients with AF is vital for the prevention of stroke and its consequences. The CHA2DS2-VASc score is used to determine AF and stroke risk based on several risk factors.[3] As part of the interaction between ethnicity, AF and stroke we need to investigate differences in risk factors, compliance of prescription and dosing.

12/05/2021

Release