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Risk of fractures in cancer survivors in the United Kingdom: a population-based matched cohort study using linked electronic health records databases

Safe People

Organisation name

London School of Hygiene and Tropical Medicine

Organisation sector

Academic Institute

Applicant name(s)

Krishnan Bhaskaran - Chief Investigator - London School of Hygiene & Tropical Medicine ( LSHTM )Krishnan Bhaskaran - Corresponding Applicant - London School of Hygiene & Tropical Medicine ( LSHTM )Eva Buzasi - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )Garth Funston - Collaborator - University of CambridgeHelen Strongman - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )Helena Carreira - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )Kathryn Mansfield - Collaborator - London School of Hygiene & Tropical Medicine ( LSHTM )

Safe Projects

Project ID

CPRD253

Lay summary

Over the past decades, earlier detection of cancer through screening programmes and better cancer treatments have improved survival for many people with cancer. However, there are concerns that some cancer treatments may have long-term effects on bone health, leading to more broken bones and consequent diminished quality of life, increased risk of death and costs to healthcare services.

Technical summary

Over the past decades, advances in cancer detection and treatment have resulted in improved survival, whilst raising concerns about long-term adverse consequences. It has been suggested that people receiving cancer therapy may experience higher rates of bone loss, osteoporosis and bone fracture. However, there is currently little population-based evidence on this. The relationship between cancer survival and bone health is important to understand considering the high burden of morbidity and mortality associated with fracture and consequent reduced quality of life, in addition to the substantial financial costs to the health service.

Latest approval date

23/04/2021

Safe Data

Dataset(s) name

HES Admitted Patient Care

ONS Death Registration Data

Patient Level Index of Multiple Deprivation

Safe Setting

Access type

Release