University of Birmingham

Academic Institute

Dipak Kotecha - Chief Investigator - University of BirminghamAlastair Mobley - Corresponding Applicant - University of BirminghamDavid Shukla - Collaborator - University of BirminghamPuja Myles - Collaborator - CPRDSamir Mehta - Collaborator - University of BirminghamSusan Beatty - Collaborator - CPRDTim Williams - Collaborator - CPRDXiaoxia Wang - Collaborator - University Hospitals Birmingham

CPRD255

This application covers work which will be conducted as part of a larger data enabled clinical trial called DaRe2THINK which has already received research ethics approval (21/NE/0021). This application requests the use of CPRD Primary Care data linked to HES Admitted Patient Care, and ONS Death Registration data to supplement the analysis of clinical outcomes.

DaRe2THINK is a MHRA (CTA 21761/0364/001-0001), and REC (21/NE/0021) approved randomised control trial. This application is seeking approval to link CPRD primary care data with both HES Admitted Patient Care and ONS Death Registration data to revolutionise the way that research is conducted in the NHS. Current RCT methodology often leads to recruitment of highly selected participants with less diversity than the clinical population. New RCT approaches are needed that can realise the value of the world-leading data quality and infrastructure of the NHS.

15/04/2021

Release