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Preventing stroke, premature death and cognitive decline in a broader community of patients with atrial fibrillation using healthcare data for pragmatic research: A randomised controlled trial (DaRe2THINK)
Safe People
Organisation name
University of Birmingham
Organisation sector
Academic Institute
Applicant name(s)
Dipak Kotecha - Chief Investigator - University of BirminghamAlastair Mobley - Corresponding Applicant - University of BirminghamDavid Shukla - Collaborator - University of BirminghamPuja Myles - Collaborator - CPRDSamir Mehta - Collaborator - University of BirminghamSusan Beatty - Collaborator - CPRDTim Williams - Collaborator - CPRDXiaoxia Wang - Collaborator - University Hospitals Birmingham
Safe Projects
Project ID
CPRD255
Lay summary
This application covers work which will be conducted as part of a larger data enabled clinical trial called DaRe2THINK which has already received research ethics approval (21/NE/0021). This application requests the use of CPRD Primary Care data linked to HES Admitted Patient Care, and ONS Death Registration data to supplement the analysis of clinical outcomes.
Technical summary
DaRe2THINK is a MHRA (CTA 21761/0364/001-0001), and REC (21/NE/0021) approved randomised control trial. This application is seeking approval to link CPRD primary care data with both HES Admitted Patient Care and ONS Death Registration data to revolutionise the way that research is conducted in the NHS. Current RCT methodology often leads to recruitment of highly selected participants with less diversity than the clinical population. New RCT approaches are needed that can realise the value of the world-leading data quality and infrastructure of the NHS.
Latest approval date
15/04/2021
Safe Data
Dataset(s) name
HES Admitted Patient Care
ONS Death Registration Data
Safe Setting
Access type
Release