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Burden of polycystic ovary syndrome during pregnancy and offspring outcomes

Safe People

Organisation name

University of Birmingham

Organisation sector

Academic Institute

Applicant name(s)

Anuradhaa Subramanian - Chief Investigator - University of BirminghamAnuradhaa Subramanian - Corresponding Applicant - University of BirminghamAstha Anand - Collaborator - University of BirminghamKrishna Gokhale - Collaborator - University of BirminghamKrishnarajah Nirantharakumar - Collaborator - University of BirminghamSiang Ing Lee - Collaborator - University of BirminghamTom Taverner - Collaborator - University of Birmingham

Safe Projects

Project ID

CPRD254

Lay summary

Polycystic ovarian syndrome (PCOS) has long been considered as a reproductive disorder. In the wake of new findings, PCOS is now identified as a metabolic disorder that affects women throughout their lifetime, and even posing intergenerational risks to their children. These risks maybe attributed to several elements of PCOS– (1) underlying androgen excess, i-e, high levels of “male” hormone, (2) insulin resistance, a driver to the development of type 2 diabetes, (3) other co-morbidities that are commonly seen among women with PCOS, and (4) drugs prescribed to them.

Technical summary

The aim of this study is to estimate the trends in incidence and prevalence of PCOS within the primary care setting and to understand the PCOS disease burden, especially among pregnant women.

Latest approval date

27/04/2021

Safe Data

Dataset(s) name

CPRD Mother-Baby Link

HES Admitted Patient Care

ONS Death Registration Data

Pregnancy Register

Safe Setting

Access type

Release