University of Nottingham

Academic Institute

Joe Kai - Chief Investigator - University of NottinghamMohana Ratnapalan - Corresponding Applicant - University of NottinghamCaroline Mitchell - Collaborator - University of SheffieldNadeem Qureshi - Collaborator - University of NottinghamRalph Kwame Akyea - Collaborator - University of NottinghamStephen Weng - Collaborator - University of NottinghamYana Vinogradova - Collaborator - University of Nottingham

CPRD257

Statins are a commonly prescribed drug which help reduce the risk of heart disease and death. They work by reducing the levels of cholesterol in your body. When cholesterol levels are measured with a blood test some people show greater reductions in cholesterol levels than others, even when prescribed the same amount of statins. We are not sure if the people with better reductions in their cholesterol levels are taking their tablets more often as prescribed or if there are other reasons. It is possible that having different health conditions and use of other medications may affect how well a person’s cholesterol levels are reduced or not.

Background and aims: Statins reduce lipid levels, which helps modify the risk of cardiovascular morbidity and death. However, there is variability in lipid response and there is some evidence that the reason for this may be modifiable. Given the growing prevalence of multimorbidity (two or more physical or mental health condition) in the population we aim to understand if this has an influence on lipid response to statins. This study aims to explore which groupings of conditions may be most important to managing lipid levels and preventing future cardiovascular disease.

29/04/2021

Release