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Effectiveness of Indapamide Sustained Released on top of Perindopril on blood pressure change: a methodological study to validate effect of anti-hypertensive drugs in Clinical Research Practice Datalink

Safe People

Organisation name

Institut de Recherches Internationales Servier (IRIS)

Organisation sector

Commercial

Applicant name(s)

CELINE DARRICARRERE - Chief Investigator - IRIS - Institut de Recherches Internationales ServierCELINE DARRICARRERE - Corresponding Applicant - IRIS - Institut de Recherches Internationales Servierdominique Procureur - Collaborator - IRIS - Institut de Recherches Internationales ServierEmmanuelle Jacquot - Collaborator - IRIS - Institut de Recherches Internationales ServierJaume Aguado - Collaborator - RTI Health SolutionsMANEL PLADEVALL - Collaborator - RTI Health SolutionsMarie MANGIN - Collaborator - IRIS - Institut de Recherches Internationales ServierMorgane Ballon - Collaborator - IRIS - Institut de Recherches Internationales ServierStéphanie HENNEL - Collaborator - IRIS - Institut de Recherches Internationales ServierVirginie SIMON - Collaborator - IRIS - Institut de Recherches Internationales ServierXabier Garcia de Albeniz - Collaborator - RTI Health Solutions

Safe Projects

Project ID

CPRD464

Lay summary

Hypertension is a chronic condition characterized by high blood pressure. It represents one of the main risk factors leading to cardiovascular diseases. In England, hypertension affects approximately 30% of men and 26% of women. Clinical guidelines for hypertension first recommend changing some lifestyle factors that could have an impact on blood pressure. These changes may be followed by the prescription of medications for hypertension.

Technical summary

Hypertension is a chronic condition characterized by high blood pressure (BP) that affects 30% of men and 26% of women in England. It is a major contributing factor to cardiovascular outcome and reduction of elevated BP can decrease cardiovascular mortality. Perindopril (tert-butylamine 4mg or arginine 5mg) and indapamide Sustained Released (SR) 1.5mg are common hypertensive treatments.

Latest approval date

31/03/2021

Safe Data

Dataset(s) name

HES Admitted Patient Care

Patient Level Index of Multiple Deprivation

Safe Setting

Access type

Release