University of Leicester

Academic Institute

Bogdan Grechuk - Chief Investigator - University of LeicesterBogdan Grechuk - Corresponding Applicant - University of LeicesterAlexander Gorban - Collaborator - University of LeicesterClare Gillies - Collaborator - University of LeicesterEvgeny Mirkes - Collaborator - University of LeicesterFrancesco Zaccardi - Collaborator - University of LeicesterKamlesh Khunti - Collaborator - University of Leicester

CPRD471

The number of people living in the UK with diabetes in all its forms is approaching 5 million. The expected lifetime of a diabetic patient is significantly lower than for a non-diabetic patient of similar age and other conditions. The analysis of diabetes-related mortality is complicated by the fact that patients rarely die from diabetes directly – instead, diabetic people have increased risk of death from other diseases. In the last decade, we have seen significant advances in treatments for Type 2 diabetes, which seem to reduce the mortality risk for many patients. However, the effect of these drugs is not yet fully understood, because many of the risk estimates are derived from data which are 10 or more years old. This project aims to develop a deeper understanding of the risks associated with Type 1 or Type 2 diabetes, analyse the risk of medical complications, and the impact of chronic conditions on life expectancy and disability. The effect of recent improved treatments will also be investigated. As a result, we will produce, for all age ranges, mortality tables at a granular level for lives with and without diabetes. We will also produce morbidity tables at a granular level for inceptions of diabetes. It is hoped that the research undertaken in this project will help to support individuals with diabetes. In particular, this will improve access to insurance products for people with diabetes.

This study investigates mortality in individuals with type 1 and type 2 diabetes compared to matched controls without diabetes. Participants will be matched on presence of risk factors, such as age, smoking status, alcohol consumption, body mass index, and other diseases. We will pay special attention to significance of risk factors, separately and in combination. We will also use the control to assess risk factors for progression to type 2 diabetes. Finally, we investigate trends as to how diabetes-related mortality and risk factors have changed over the past 10 years.

07/04/2021

Release