University of Leicester

Academic Institute

Francesco Zaccardi - Chief Investigator - University of LeicesterKajal Panchal - Corresponding Applicant - University of LeicesterClaire Lawson - Collaborator - University of LeicesterKamlesh Khunti - Collaborator - University of Leicester

CPRD680

People with diabetes have an increased risk of heart failure, a condition where the heart is unable to pump enough blood around the body. Previous studies have shown that heart failure frequently follows a disease, affecting arteries of the heart, defined as ischaemic heart disease (e.g angina and myocardial infarction) and is characterised by a reduced amount of oxygen to the heart. Recent evidence suggests that a higher frequency of patients with diabetes could be presenting with heart failure without previous ischaemic heart disease. However, whether the risk of heart failure has changed over time, relative to myocardial infarction is unknown. Furthermore, whether there are differences by age, sex, ethnicity, and type of diabetes remains uncertain. The main aim of this study is to investigate the change over time in the incidence of heart failure compared to that of ischaemic heart disease in patients with diabetes. In addition, we will explore whether the incidence is related to prognostic factors such as age, sex, ethnicity, medications and other related. This research is necessary for aiding the development of more tailored prevention and management approaches for diabetes.

Patients with diabetes have an increased risk of heart failure (HF). Most HF cases tend to present with prior diagnosis of ischaemic heart disease (IHD), such as myocardial infarction. However, in patients with and without diabetes there have been significant improvements in the treatment of risk factors associated with IHD, resulting in reducing trends in myocardial infarction. As such, a higher proportion of HF cases may have not been driven by IHD in the last years, by which glucose can directly affect HF without IHD. This is relevant since it is unknown whether this phenotype transition has occurred. Moreover, whether there are differences by risk factors or diabetes type remains unclear.

24/03/2021

Release