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A Case Control and Cohort Design Study, using Multi-state Models, Analysis of Treatment Patterns in Chronic Obstructive Pulmonary Disease and Asthma.

Safe People

Organisation name

Twist Health

Organisation sector

Commercial

Applicant name(s)

Abi Mawer - Chief Investigator - Twist HealthAbi Mawer - Corresponding Applicant - Twist HealthAmy Mulick - Collaborator - Twist HealthJames Jordan - Collaborator - NHS ScotlandLina Eliasson - Collaborator - Twist HealthMagdalena Murawska - Collaborator - Twist HealthRebecca Sarson - Collaborator - Twist HealthStephanie Best - Collaborator - Twist Health

Safe Projects

Project ID

CPRD688

Lay summary

A description of the treatment patterns observed in patients with Chronic Obstructive Pulmonary Disease (COPD) and Asthma from diagnosis until the most recent data available. We will analyse the probability of switching from one treatment to another over time and compare this between controlled and uncontrolledpatients.

Technical summary

This project uses linked primary and secondary care data from England to model the probability of transition from one treatment to the next given the current treatment and time of the transition. Due to the lack of pilot data, we do not put any hypothesis about the estimated transition, occupation probabilities or of the dependence of these probabilities on any baseline features.Therefore, we do not plan to adjust for baseline variables. The purpose of this study is to estimate probabilities.

Latest approval date

18/03/2021

Safe Data

Dataset(s) name

HES Accident and Emergency

HES Admitted Patient Care

Safe Setting

Access type

Release