University of Glasgow

Academic Institute

Michael Fleming - Chief Investigator - University of GlasgowMichael Fleming - Corresponding Applicant - University of GlasgowClaire Hastie - Collaborator - University of GlasgowDaniel Mackay - Collaborator - University of GlasgowDavid Blane - Collaborator - University of GlasgowJames McLay - Collaborator - University of AberdeenJill Pell - Collaborator - University of Glasgow

CPRD851

The prescribing of medicines to treat hypertension in pregnant women are avoided wherever possible because they can affect the development of, and cause harm to, the baby in the womb. However, sometimes the need to prescribe these medicines, referred to as antihypertensive medication, cannot be avoided. Harmful effects on the baby, which are immediately obvious at birth, have been reported for these medicines. Less is known however about the type of longer-term harm they may cause the baby in the womb, which may only be obvious in later years.

We will investigate pregnancy and child outcomes for women prescribed antihypertensive medications during pregnancy compared to a) women with hypertension who did not receive antihypertensive medication and b) women who did not have hypertension and did not receive antihypertensive medication. We will ascertain all women with pregnancies ending between 1st January 1991 and 31st December 2020 and link mother's Clinical Practice Research Datalink (CPRD) primary care and prescribing data to their children's CPRD primary care and prescribing, Hospital Episode Statistics (HES) inpatient admission, and Office for National Statistics (ONS) death data.

10/02/2021

Release