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Does the association between multiple long-term conditions and mortality risk vary across sociodemographic groups?

Safe People

Organisation name

The Health Foundation

Organisation sector

Independent Sector Organisation

Applicant name(s)

Mai Stafford - Chief Investigator - The Health FoundationMai Stafford - Corresponding Applicant - The Health FoundationAnne Alarilla - Collaborator - The Health FoundationElizabeth Crellin - Collaborator - The Health FoundationHannah Knight - Collaborator - The Health FoundationJay Hughes - Collaborator - The Health Foundation

Safe Projects

Project ID

CPRD850

Lay summary

The coronavirus pandemic has highlighted differences in risk of poor outcomes between groups based on their ethnic background, level of deprivation, age and sex. Before the pandemic, inequalities in many other health conditions were clear. Living in socioeconomically deprived circumstances or being from certain ethnic minority groups is linked to having multiple long-term conditions. But we do not yet know whether these social and economic factors are also linked to poorer survival once a person has developed these conditions.

Technical summary

Prevalence of multiple long-term conditions is higher and age of onset lower among those who are socioeconomically disadvantaged, or from black, Asian and some other minority ethnic groups. Current evidence is mixed on whether deprivation, ethnicity, sex and their intersection modify prognosis once multiple conditions are established. This study will quantify the association between multiple conditions and mortality risk and test effect modifiers. This information could be used to identify sociodemographic groups with multiple conditions that have higher mortality risk and may benefit from targeted care. The coronavirus pandemic has made this issue even more pressing. People with multiple conditions are high users of health care and some may have been especially impacted by disruptions to health care services during the pandemic.

Latest approval date

02/03/2021

Safe Data

Dataset(s) name

HES Admitted Patient Care

ONS Death Registration Data

Patient Level Index of Multiple Deprivation

Safe Setting

Access type

Release