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Incidence and prevalence of heart failure in patients with idiopathic pulmonary fibrosis (IPF) between 2010 - 2019 and the impact of heart failure treatment on IPF mortality: a population-based study using CPRD Aurum

Safe People

Organisation name

Imperial College London

Organisation sector

Academic Institute

Applicant name(s)

Jennifer Quint - Chief Investigator - Imperial College LondonArdita Koteci - Corresponding Applicant - Imperial College LondonAnn Morgan - Collaborator - Imperial College LondonHannah Whittaker - Collaborator - Imperial College LondonLaura Portas - Collaborator - Imperial College LondonPeter George - Collaborator - Royal Brompton Hospital

Safe Projects

Project ID

CPRD870

Lay summary

Idiopathic pulmonary fibrosis (IPF) is a chronic condition of unknown cause resulting in scarring of the lungs. It is more common in men, with older age and smoking being additional risk factors. Currently, there are no treatments available that can cure the disease, only medications that can slow the rate of scarring. IPF has a very poor prognosis, with the average patient surviving only 3-4 years post diagnosis, an outlook which is worse than several cancers.

Technical summary

Idiopathic pulmonary fibrosis (IPF) is a progressive lung condition of unknown aetiology, resulting in irreversible lung scarring. Multimorbidity is common in IPF and a risk factor for reduced survival. In particular, cardiovascular diseases are the most prevalent comorbidity and significant risk factors for increased mortality.

Latest approval date

27/01/2021

Safe Data

Dataset(s) name

HES Admitted Patient Care

ONS Death Registration Data

Patient Level Index of Multiple Deprivation

Safe Setting

Access type

Release