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CCU106: Impact of the COVID-19 pandemic on cardiovascular risk in patients with and without kidney disease
Safe People
Organisation name
University of Edinburgh
Organisation sector
Academic Institute
Applicant name(s)
Gavin Chapman
Funders/ Sponsors
Safe Projects
Project ID
CCU106
Lay summary
Kidney disease is a major health issue, affecting ~20% of adults over the age of 35 in England. Heart disease – including heart attacks, heart failure and stroke – is the commonest cause of death in patients with kidney disease, and this risk increases as kidney function declines. In patients with kidney disease, COVID-19 led to worse outcomes, in particular an increased risk of death from heart disease, and the pandemic resulted in disruptions to routine kidney care. Our study will be the first to explore how rates of kidney and heart disease diagnosis changed before, during and after the COVID-19 pandemic. We will assess the impact of the COVID-19 pandemic on patient treatment and outcomes and, through analysing large datasets, we aim to uncover whether any disparities exist based on age, sex, ethnicity and socioeconomic status.
Public benefit statement
Our study will determine both the short- and long-term effects of the COVID-19 pandemic on treatment and outcomes of heart disease. Critically, we will identify if any disparities in treatment exist between those with and without kidney disease. We will also establish whether management of kidney disease changed during the pandemic. Finally, we will identify whether inequalities exist (e.g., based on age, sex, ethnicity, or socioeconomic status) in the healthcare patients receive and their outcomes. As part of this, we will establish if there were any disparities in rate of COVID-19 vaccination (e.g., based on age, sex, ethnicity, socioeconomic status) and whether this impacted on treatment and outcomes of heart disease and kidney disease. These findings will inform policymakers to change healthcare delivery to address any inequities we identify. Visit the BHF Data Science Centre website for more detailed information about project outputs. https://bhfdatasciencecentre.org/projects/ccu106/
Technical summary
This project accessed the following datasets within the Trusted Research Environment(s) for CVD-COVID-UK / COVID-IMPACT: - ENGLAND: - Civil Registration - Deaths - COVID-19 Vaccination Status - Emergency Care Data Set (ECDS) - GPES Data for Pandemic Planning and Research (COVID-19) - Hospital Episode Statistics Accident and Emergency - Hospital Episode Statistics Admitted Patient Care - Hospital Episode Statistics Critical Care - Hospital Episode Statistics Outpatients - Medicines dispensed in Primary Care (NHSBSA data) - NICOR – MINAP: Myocardial Ischaemia National Audit Project - NICOR – NHFA: National Heart Failure Audit - NICOR – PCI: Percutaneous Coronary Interventions - Sentinel Stroke National Audit Programme Clinical Dataset
Other approval committees
Project start date
01/05/2025
Project end date
31/12/2025
Latest approval date
02/04/2025
Safe Data
Dataset(s) name
Data sensitivity level
De-Personalised
Release/Access date
01/05/2025
Safe Setting
Access type
TRE